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Research ArticleRHEUMATIC DISEASE
Using genetics to prioritize diagnoses for rheumatology outpatients with inflammatory arthritis
- View ORCID ProfileRachel Knevel1,2,3,
- View ORCID ProfileSaskia le Cessie4,
- View ORCID ProfileChikashi C. Terao5,6,7,
- View ORCID ProfileKamil Slowikowski3,8,9,10,
- Jing Cui1,
- View ORCID ProfileTom W. J. Huizinga2,
- Karen H. Costenbader1,
- View ORCID ProfileKatherine P. Liao1,11,
- Elizabeth W. Karlson1 and
- View ORCID ProfileSoumya Raychaudhuri1,3,8,9,10,12,*
- 1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 2Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
- 3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
- 4Department of Clinical Epidemiology and Department of Biomedical Data Sciences, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
- 5Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
- 6Clinical Research Center, Shizuoka General Hospital, Shizuoka 230-0045, Japan.
- 7Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 420-8527, Japan.
- 8Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 9Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
- 10Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
- 11Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.
- 12Centre for Genetics and Genomics Versus Arthritis and Centre for Musculoskeletal Research, Manchester M13 9PL, UK.
- ↵*Corresponding author. Email: soumya{at}broadinstitute.org
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Science Translational Medicine 27 May 2020:
Vol. 12, Issue 545, eaay1548
DOI: 10.1126/scitranslmed.aay1548
Vol. 12, Issue 545, eaay1548
DOI: 10.1126/scitranslmed.aay1548
Rachel Knevel
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
2Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Saskia le Cessie
4Department of Clinical Epidemiology and Department of Biomedical Data Sciences, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
Chikashi C. Terao
5Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
6Clinical Research Center, Shizuoka General Hospital, Shizuoka 230-0045, Japan.
7Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 420-8527, Japan.
Kamil Slowikowski
3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
8Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
9Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
10Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Jing Cui
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Tom W. J. Huizinga
2Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
Karen H. Costenbader
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Katherine P. Liao
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
11Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.
Elizabeth W. Karlson
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Soumya Raychaudhuri
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
8Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
9Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
10Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
12Centre for Genetics and Genomics Versus Arthritis and Centre for Musculoskeletal Research, Manchester M13 9PL, UK.
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