Research ArticleBLOOD-BRAIN BARRIER

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

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Science Translational Medicine  27 May 2020:
Vol. 12, Issue 545, eaay1163
DOI: 10.1126/scitranslmed.aay1163

Article Information

vol. 12 no. 545

PubMed: 
Print ISSN: 
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History: 
  • Received for publication May 22, 2019
  • Resubmitted February 10, 2020
  • Accepted for publication April 2, 2020
  • .

Author Information

  1. Julie C. Ullman1,*,
  2. Annie Arguello1,*,
  3. Jennifer A. Getz1,*,
  4. Akhil Bhalla1,
  5. Cathal S. Mahon1,
  6. Junhua Wang1,
  7. Tina Giese1,
  8. Catherine Bedard1,
  9. Do Jin Kim1,
  10. Jessica R. Blumenfeld1,
  11. Nicholas Liang1,
  12. Ritesh Ravi1,
  13. Alicia A. Nugent1,
  14. Sonnet S. Davis1,
  15. Connie Ha1,
  16. Joseph Duque1,
  17. Hai L. Tran1,
  18. Robert C. Wells1,
  19. Steve Lianoglou1,
  20. Vinay M. Daryani1,
  21. Wanda Kwan1,
  22. Hilda Solanoy1,
  23. Hoang Nguyen1,
  24. Timothy Earr1,
  25. Jason C. Dugas1,
  26. Michael D. Tuck2,
  27. Jennifer L. Harvey2,
  28. Michelle L. Reyzer2,
  29. Richard M. Caprioli2,
  30. Sejal Hall1,,
  31. Suresh Poda1,
  32. Pascal E. Sanchez1,
  33. Mark S. Dennis1,
  34. Kannan Gunasekaran1,
  35. Ankita Srivastava1,
  36. Thomas Sandmann1,
  37. Kirk R. Henne1,
  38. Robert G. Thorne1,
  39. Gilbert Di Paolo1,
  40. Giuseppe Astarita1,
  41. Dolores Diaz1,
  42. Adam P. Silverman1,
  43. Ryan J. Watts1,
  44. Zachary K. Sweeney1,
  45. Mihalis S. Kariolis1, and
  46. Anastasia G. Henry1,
  1. 1Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, CA 94080, USA.
  2. 2Mass Spectrometry Research Center, Vanderbilt University, 9160 MRB III, 465 21 Avenue South, Nashville, TN 37240, USA.
  1. Corresponding author. Email: kariolis{at}dnli.com (M.S.K.); henry{at}dnli.com (A.G.H.)
  • * These authors contributed equally to this work.

  • Present address: Audentes Therapeutics, 600 California St., San Francisco, CA 94108, USA.

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May 202050071714905
Jun 2020296911801002
Jul 2020580282263
Aug 2020522245169
Sep 2020415203115
Oct 2020431169126
Nov 2020327160108
Dec 2020238142104
Jan 2021333164110
Feb 2021393225155
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