Research ArticleMalaria

An open-label phase 1/2a trial of a genetically modified rodent malaria parasite for immunization against Plasmodium falciparum malaria

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Science Translational Medicine  20 May 2020:
Vol. 12, Issue 544, eaay2578
DOI: 10.1126/scitranslmed.aay2578

Article Information

vol. 12 no. 544

Print ISSN: 
Online ISSN: 
  • Received for publication June 4, 2019
  • Accepted for publication April 22, 2020
  • .

Author Information

  1. Isaie J. Reuling1,*,
  2. António M. Mendes2,*,
  3. Gerdie M. de Jong3,*,
  4. Amanda Fabra-García1,*,
  5. Helena Nunes-Cabaço2,*,
  6. Geert-Jan van Gemert1,
  7. Wouter Graumans1,
  8. Luc E. Coffeng4,
  9. Sake J. de Vlas4,
  10. Annie S. P. Yang1,
  11. Cynthia Lee5,
  12. Yimin Wu5,
  13. Ashley J. Birkett5,
  14. Christian F. Ockenhouse5,
  15. Rob Koelewijn3,
  16. Jaap J. van Hellemond3,
  17. Perry J. J. van Genderen3,6,,
  18. Robert W. Sauerwein1, and
  19. Miguel Prudêncio2,
  1. 1Radboud Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
  2. 2Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal.
  3. 3Department of Medical Microbiology and Infectious Diseases, Erasmus MC, 3015 GD Rotterdam, Netherlands.
  4. 4Department of Public Health, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, Netherlands.
  5. 5PATH’s Malaria Vaccine Initiative, Washington, DC 20001, USA.
  6. 6Corporate Travel Clinic Erasmus MC, 3015 CP Rotterdam, Netherlands.
  1. Corresponding author. Email: mprudencio{at} (M.P.); robert.sauerwein{at} (R.W.S.); p.vangenderen{at} (P.J.J.v.G.)
  • * These authors contributed equally to this work.


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