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Research ArticleBone
ATRAID regulates the action of nitrogen-containing bisphosphonates on bone
- View ORCID ProfileLauren E. Surface1,*,
- View ORCID ProfileDamon T. Burrow2,
- View ORCID ProfileJinmei Li2,
- View ORCID ProfileJiwoong Park2,
- View ORCID ProfileSandeep Kumar2,
- View ORCID ProfileCheng Lyu2,
- View ORCID ProfileNiki Song2,
- Zhou Yu1,†,
- Abbhirami Rajagopal3,‡,
- View ORCID ProfileYangjin Bae3,
- View ORCID ProfileBrendan H. Lee3,
- View ORCID ProfileSteven Mumm2,4,
- View ORCID ProfileCharles C. Gu5,
- View ORCID ProfileJonathan C. Baker6,
- Mahshid Mohseni2,
- Melissa Sum7,
- Margaret Huskey2,
- View ORCID ProfileShenghui Duan2,
- View ORCID ProfileVinieth N. Bijanki4,
- View ORCID ProfileRoberto Civitelli2,
- Michael J. Gardner8,
- View ORCID ProfileChris M. McAndrew9,
- William M. Ricci10,
- View ORCID ProfileChristina A. Gurnett9,11,
- View ORCID ProfileKathryn Diemer2,
- View ORCID ProfileFei Wan12,
- View ORCID ProfileChristina L. Costantino13,
- Kristen M. Shannon14,
- Noopur Raje14,
- View ORCID ProfileThomas B. Dodson15,§,
- View ORCID ProfileDaniel A. Haber14,16,
- Jan E. Carette17,
- View ORCID ProfileMalini Varadarajan18,
- View ORCID ProfileThijn R. Brummelkamp19,20,21,
- View ORCID ProfileKivanc Birsoy22,
- View ORCID ProfileDavid M. Sabatini16,23,24,25,
- View ORCID ProfileGabe Haller11,26 and
- View ORCID ProfileTimothy R. Peterson2,27,28,||
- 1Department of Molecular and Cellular Biology, Department of Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.
- 2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
- 3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
- 4Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St. Louis, MO 63110, USA.
- 5Division of Biostatistics, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8067, St. Louis, MO 63110, USA.
- 6Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., St. Louis, MO 63110, USA.
- 7Division of Endocrinology, Diabetes and Metabolism, NYU Langone Health, 530 1st Ave., Schwartz 5E., New York, NY 10016, USA.
- 8Department of Orthopedic Surgery, Stanford University, 450 Broadway Street, Redwood City, CA 94063, USA.
- 9Department of Orthopedic Surgery, Washington University School of Medicine, 4938 Parkview Place, St. Louis, MO 63110, USA.
- 10Hospital for Special Surgery Main Campus–Belaire Building, 525 East 71st Street 2nd Floor, New York, NY 10021, USA.
- 11Department of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
- 12Department of Surgery, Washington University School of Medicine, Campus Box 8109, 4590 Children’s Place, Suite 9600, St. Louis, MO 63110, USA.
- 13Massachusetts General Hospital Cancer Center and Department of Surgery, Harvard Medical School, Boston, MA 02114, USA.
- 14Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
- 15Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA 02114, USA.
- 16Howard Hughes Medical Institute (HHMI), Chevy Chase, MD 20815, USA.
- 17Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
- 18Oncology Disease Area, Novartis Institutes for BioMedical Research, Cambridge, CA 02140, USA.
- 19Oncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, Netherlands.
- 20CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
- 21Cancer Genomics Center, Plesmanlaan 121, 1066CX Amsterdam, Netherlands.
- 22The Rockefeller University, 1230 York Ave., New York, NY 10065, USA.
- 23Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02139, USA.
- 24Department of Biology, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
- 25David H. Koch Center for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
- 26Department of Neurosurgery, Washington University School of Medicine, Campus Box 8057, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
- 27Department of Genetics, Washington University School of Medicine, 4515 McKinley Ave. Campus Box 8232, St. Louis, MO 63110, USA.
- 28Institute for Public Health, Washington University School of Medicine, 600 S. Taylor Suite 2400, Campus Box 8217, St. Louis, MO 63110, USA.
- ↵||Corresponding author. Email: timrpeterson{at}wustl.edu
↵* Present address: Endocrine Unit, 55 Fruit St., Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
↵† Present address: Howard Hughes Medical Institute (HHMI) Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.
↵‡ Present address: Harris County Public Health, Houston, TX 77027, USA.
↵§ Present address: Department of Oral and Maxillofacial Surgery, University of Washington School of Dentistry, Seattle, WA 98195, USA.
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Science Translational Medicine 20 May 2020:
Vol. 12, Issue 544, eaav9166
DOI: 10.1126/scitranslmed.aav9166
Vol. 12, Issue 544, eaav9166
DOI: 10.1126/scitranslmed.aav9166
Lauren E. Surface
1Department of Molecular and Cellular Biology, Department of Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.
Damon T. Burrow
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Jinmei Li
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Jiwoong Park
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Sandeep Kumar
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Cheng Lyu
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Niki Song
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Zhou Yu
1Department of Molecular and Cellular Biology, Department of Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.
Abbhirami Rajagopal
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Yangjin Bae
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Brendan H. Lee
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Steven Mumm
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
4Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St. Louis, MO 63110, USA.
Charles C. Gu
5Division of Biostatistics, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8067, St. Louis, MO 63110, USA.
Jonathan C. Baker
6Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., St. Louis, MO 63110, USA.
Mahshid Mohseni
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Melissa Sum
7Division of Endocrinology, Diabetes and Metabolism, NYU Langone Health, 530 1st Ave., Schwartz 5E., New York, NY 10016, USA.
Margaret Huskey
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Shenghui Duan
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Vinieth N. Bijanki
4Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St. Louis, MO 63110, USA.
Roberto Civitelli
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Michael J. Gardner
8Department of Orthopedic Surgery, Stanford University, 450 Broadway Street, Redwood City, CA 94063, USA.
Chris M. McAndrew
9Department of Orthopedic Surgery, Washington University School of Medicine, 4938 Parkview Place, St. Louis, MO 63110, USA.
William M. Ricci
10Hospital for Special Surgery Main Campus–Belaire Building, 525 East 71st Street 2nd Floor, New York, NY 10021, USA.
Christina A. Gurnett
9Department of Orthopedic Surgery, Washington University School of Medicine, 4938 Parkview Place, St. Louis, MO 63110, USA.
11Department of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
Kathryn Diemer
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Fei Wan
12Department of Surgery, Washington University School of Medicine, Campus Box 8109, 4590 Children’s Place, Suite 9600, St. Louis, MO 63110, USA.
Christina L. Costantino
13Massachusetts General Hospital Cancer Center and Department of Surgery, Harvard Medical School, Boston, MA 02114, USA.
Kristen M. Shannon
14Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
Noopur Raje
14Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
Thomas B. Dodson
15Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA 02114, USA.
Daniel A. Haber
14Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
16Howard Hughes Medical Institute (HHMI), Chevy Chase, MD 20815, USA.
Jan E. Carette
17Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Malini Varadarajan
18Oncology Disease Area, Novartis Institutes for BioMedical Research, Cambridge, CA 02140, USA.
Thijn R. Brummelkamp
19Oncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, Netherlands.
20CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
21Cancer Genomics Center, Plesmanlaan 121, 1066CX Amsterdam, Netherlands.
Kivanc Birsoy
22The Rockefeller University, 1230 York Ave., New York, NY 10065, USA.
David M. Sabatini
16Howard Hughes Medical Institute (HHMI), Chevy Chase, MD 20815, USA.
23Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02139, USA.
24Department of Biology, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
25David H. Koch Center for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Gabe Haller
11Department of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
26Department of Neurosurgery, Washington University School of Medicine, Campus Box 8057, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
Timothy R. Peterson
2Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
27Department of Genetics, Washington University School of Medicine, 4515 McKinley Ave. Campus Box 8232, St. Louis, MO 63110, USA.
28Institute for Public Health, Washington University School of Medicine, 600 S. Taylor Suite 2400, Campus Box 8217, St. Louis, MO 63110, USA.
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