20 May 2020
Vol 12, Issue 544

About The Cover

Cover image expansion

ONLINE COVER Protective Parasites. Conventional approaches have failed to yield a protective vaccine against malaria, a disease transmitted by mosquitos to millions of people each year. Two new studies tested vaccines made from genetically engineered malaria parasites. Reuling et al. immunized malaria-naïve adults with PbVac, a rodent-specific parasite that expresses the Plasmodium falciparum circumsporozoite protein. Using P. falciparum attenuated by deletion of two genes, Roestenberg et al. similarly immunized malaria-naïve adults with PfSPZ-GA1. Both vaccines were immunogenic and appeared to be well tolerated, but controlled exposure of vaccinated volunteers to malaria-infected mosquitoes indicated suboptimal protection. Genetically engineered vaccines such as these could help in the fight against malaria. [CREDIT: WARWICK SLOSS/MINDEN PICTURES]