Research ArticleHIV

Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target

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Science Translational Medicine  13 May 2020:
Vol. 12, Issue 543, eaaz0802
DOI: 10.1126/scitranslmed.aaz0802

Article Information

vol. 12 no. 543

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 10, 2019
  • Resubmitted October 29, 2019
  • Accepted for publication April 17, 2020
  • .

Author Information

  1. Runxia Liu1,*,
  2. Yang-Hui Jimmy Yeh1,*,
  3. Ales Varabyou2,*,
  4. Jack A. Collora1,
  5. Scott Sherrill-Mix3,
  6. C. Conover Talbot Jr.4,
  7. Sameet Mehta5,
  8. Kristen Albrecht1,
  9. Haiping Hao4,
  10. Hao Zhang6,
  11. Ross A. Pollack7,
  12. Subul A. Beg7,
  13. Rachela M. Calvi8,
  14. Jianfei Hu9,
  15. Christine M. Durand7,
  16. Richard F. Ambinder7,
  17. Rebecca Hoh10,
  18. Steven G. Deeks10,
  19. Jennifer Chiarella8,
  20. Serena Spudich8,
  21. Daniel C. Douek9,
  22. Frederic D. Bushman3,
  23. Mihaela Pertea2,11 and
  24. Ya-Chi Ho1,
  1. 1Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
  2. 2Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  3. 3Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  4. 4Institute for Basic Biomedical Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  5. 5Yale Center for Genome Analysis, Yale University, New Haven, CT 06519, USA.
  6. 6Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  7. 7Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  8. 8Department of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA.
  9. 9Vaccine Research Center, National Institute of Health, Bethesda, MD 20892, USA.
  10. 10Department of Medicine, University of California, San Francisco, CA 94110, USA.
  11. 11Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  1. Corresponding author. Email: ya-chi.ho{at}yale.edu
  • * These authors contributed equally to this work.

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