Research ArticleHIV

Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target

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Science Translational Medicine  13 May 2020:
Vol. 12, Issue 543, eaaz0802
DOI: 10.1126/scitranslmed.aaz0802

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Sorting out HIV

The latent reservoir of HIV-1–infected cells that persist in, otherwise, virally suppressed individuals constitutes the major barrier to cure. Liu et al. developed a method called HIV-1 SortSeq to identify rare HIV-infected CD4+ T cells from individuals on antiretroviral therapies upon latency reversal ex vivo. Analysis of the isolated single cells showed that the 5′ long terminal repeat of HIV-1 was capable of driving the transcription of host genes downstream of the integration site, which may contribute to HIV persistence.

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