Research ArticleMalaria

Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization

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Science Translational Medicine  13 May 2020:
Vol. 12, Issue 543, eaay8924
DOI: 10.1126/scitranslmed.aay8924

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Predicting protection

A highly effective malaria vaccine would save many lives but correlates of protection remain ill-defined. Moncunill et al. studied peripheral blood cells isolated from individuals that had received sporozoites under chemoprophylaxis or the RTS,S vaccine. Transcriptomic analysis of gene expression after in vitro stimulation of cells revealed preimmunization and postimmunization signatures, which were validated with separate cohorts. The preimmunization signatures hint at mechanisms of differential vaccine responses between individuals; once validated in additional studies, the postimmunization signatures could be used as a surrogate for protection in clinical trials, possibly accelerating vaccine development.

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