Research ArticleKidney Disease

Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI

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Science Translational Medicine  13 May 2020:
Vol. 12, Issue 543, eaay7591
DOI: 10.1126/scitranslmed.aay7591

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A nuclear option for acute kidney injury

Acute kidney injury is a life-threatening health problem with many potential causes such as hypoxic injury, toxins, and sepsis. Patients can recover with supportive care, but they may have long-lasting kidney damage that increases the risk of chronic kidney disease, and there is no specific targeted treatment. Yu et al. discovered that nuclear receptor PXR is down-regulated in the setting of acute kidney injury, which contributes to the impairment of mitochondrial function. Conversely, interventions that restored PXR function in mouse models of acute kidney injury were effective at protecting the kidneys, suggesting the potential for a therapeutic approach targeting PXR.

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