Contents
13 May 2020
Vol 12, Issue 543
Vol 12, Issue 543
Research Articles
- PET ligands [18F]LSN3316612 and [11C]LSN3316612 quantify O-linked-β-N-acetyl-glucosamine hydrolase in the brain
Two radioligands, [18F]LSN3316612 and [11C]LSN3316612, image and quantify brain O-linked-β-N-acetyl-glucosamine hydrolase in vivo.
- Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI
PXR is crucial for protecting against AKI by targeting the AKR1B7/mitochondrial metabolism axis.
- Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization
Transcriptomic signatures before and after immunization predict protection against malaria induced by sporozoite and RTS,S/AS01E immunization.
- Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target
Single-cell transcriptome analysis by HIV-1 SortSeq identifies HIV-1–driven aberrant host gene transcription as a mechanism of HIV-1 persistence.
- ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension
ACTRIIA-Fc, an activin and GDF8/11 ligand trap, improves hemodynamics and exerts antiremodeling effects in experimental pulmonary hypertension.
Editors' Choice
- CRISPR-engineered immune cells reach the bedside
In a clinical trial, CRISPR editing of T cells to fight lung cancer was feasible and safe.
- COVID-19 and cancer: The bad and the ugly
Patients with cancer are more vulnerable to COVID-19 infection with higher risk of severe symptoms and death.
- Shedding light on venous thromboembolism
A preclinical deep vein thrombosis model was developed in mice using blood flow restriction and illumination.
About The Cover
ONLINE COVER Untangling Tauopathies. Here we see magnetic resonance and positron emission tomography (PET) images (left and right, respectively) of a healthy human brain. Lu et al. developed two radioligands compatible with PET imaging to visualize and quantify an enzyme involved in posttranslational modification of tau, which can alter tau's aggregation. Tau accumulates in tangles in neurodegenerative diseases such as Alzheimer's disease. The radioligands detected their target enzyme in postmortem brain tissue from rodents and humans with Alzheimer's disease, and brain uptake of the radioligands was visualized by PET imaging in healthy nonhuman primates and people. The radioligands could assist with drug development for tauopathies by monitoring target engagement in the brain. [CREDIT: LU ET AL./SCIENCE TRANSLATIONAL MEDICINE]
