13 May 2020
Vol 12, Issue 543

About The Cover

Cover image expansion

ONLINE COVER Untangling Tauopathies. Here we see magnetic resonance and positron emission tomography (PET) images (left and right, respectively) of a healthy human brain. Lu et al. developed two radioligands compatible with PET imaging to visualize and quantify an enzyme involved in posttranslational modification of tau, which can alter tau's aggregation. Tau accumulates in tangles in neurodegenerative diseases such as Alzheimer's disease. The radioligands detected their target enzyme in postmortem brain tissue from rodents and humans with Alzheimer's disease, and brain uptake of the radioligands was visualized by PET imaging in healthy nonhuman primates and people. The radioligands could assist with drug development for tauopathies by monitoring target engagement in the brain. [CREDIT: LU ET AL./SCIENCE TRANSLATIONAL MEDICINE]