Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

Johanna M. Eberhard; Mathieu Angin; Caroline Passaes; Maria Salgado; Valerie Monceaux; Elena Knops; Guido Kobbe; Björn Jensen; Maximilian Christopeit; Nicolaus Kröger; Linos Vandekerckhove; Jon Badiola; Alessandra Bandera; Kavita Raj; Jan van Lunzen; Gero Hütter; Jürgen H. E. Kuball; Carolina Martinez-Laperche; Pascual Balsalobre; Mi Kwon; José L. Díez-Martín; Monique Nijhuis; Annemarie Wensing; Javier Martinez-Picado; Julian Schulze zur Wiesch; Asier Sáez-Cirión

doi:10.1126/scitranslmed.aay9355

Research ArticleHIV

Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

View ORCID ProfileJohanna M. Eberhard¹,²,
View ORCID ProfileMathieu Angin³,
View ORCID ProfileCaroline Passaes³,
View ORCID ProfileMaria Salgado⁴,
Valerie Monceaux³,
View ORCID ProfileElena Knops⁵,
View ORCID ProfileGuido Kobbe⁶,
View ORCID ProfileBjörn Jensen⁷,
View ORCID ProfileMaximilian Christopeit⁸,
Nicolaus Kröger⁸,
Linos Vandekerckhove⁹,
View ORCID ProfileJon Badiola¹⁰,
View ORCID ProfileAlessandra Bandera¹¹,
Kavita Raj¹²,
Jan van Lunzen¹,¹³,
Gero Hütter¹⁴,
View ORCID ProfileJürgen H. E. Kuball¹⁵,
View ORCID ProfileCarolina Martinez-Laperche¹⁶,
Pascual Balsalobre¹⁶,
View ORCID ProfileMi Kwon¹⁶,
José L. Díez-Martín¹⁶,
View ORCID ProfileMonique Nijhuis¹⁵,
View ORCID ProfileAnnemarie Wensing ¹⁵,
View ORCID ProfileJavier Martinez-Picado ⁴,¹⁷,¹⁸,
View ORCID ProfileJulian Schulze zur Wiesch ¹,²,*,† and
View ORCID ProfileAsier Sáez-Cirión ³,*,†

¹1. Department of Medicine, Infectious Diseases Unit, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.
²DZIF Partner Site (German Center for Infection Research), Hamburg-Lübeck-Borstel-Riems Site, Hamburg, Germany.
³Institut Pasteur, HIV, Inflammation and Persistence, 75015 Paris, France.
⁴AIDS Research Institute IrsiCaixa, 08916 Badalona, Spain.
⁵Institute of Virology, University of Cologne, 50935 Cologne, Germany.
⁶Department of Haematology, Oncology, and Clinical Immunology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.
⁷Department of Gastroenterology, Hepatology, and Infectious Diseases, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.
⁸Department of Stem Cell Transplantation, University Medical Center HamburgEppendorf, 20246 Hamburg, Germany.
⁹HIV Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital, B-9000 Ghent, Belgium.
¹⁰Hematology Department, Virgen de las Nieves University Hospital, 18014 Granada, Spain.
¹¹San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, Italy.
¹²Department of Haematology, King's College Hospital, London SE5 9RS, UK.
¹³ViiV Healthcare, Brentford, Middlesex TW8 9GS, UK.
¹⁴Cellex, 01307 Dresden, Germany.
¹⁵University Medical Center Utrecht, 3584 CX, Utrecht, Netherlands.
¹⁶Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitarias Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain.
¹⁷UVic-UCC, 08500 Vic, Spain.
¹⁸ICREA, 08010 Barcelona, Spain.

↵†Corresponding author. Email: asier.saez-cirion{at}pasteur.fr (A.S.-C.); julianszw{at}gmail.com (J.S.Z.W.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 06 May 2020:
Vol. 12, Issue 542, eaay9355
DOI: 10.1126/scitranslmed.aay9355

Johanna M. Eberhard

11. Department of Medicine, Infectious Diseases Unit, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.

2DZIF Partner Site (German Center for Infection Research), Hamburg-Lübeck-Borstel-Riems Site, Hamburg, Germany.

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Mathieu Angin

3Institut Pasteur, HIV, Inflammation and Persistence, 75015 Paris, France.

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Caroline Passaes

3Institut Pasteur, HIV, Inflammation and Persistence, 75015 Paris, France.

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Maria Salgado

4AIDS Research Institute IrsiCaixa, 08916 Badalona, Spain.

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Valerie Monceaux

3Institut Pasteur, HIV, Inflammation and Persistence, 75015 Paris, France.

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Elena Knops

5Institute of Virology, University of Cologne, 50935 Cologne, Germany.

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Guido Kobbe

6Department of Haematology, Oncology, and Clinical Immunology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.

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Björn Jensen

7Department of Gastroenterology, Hepatology, and Infectious Diseases, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.

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Maximilian Christopeit

8Department of Stem Cell Transplantation, University Medical Center HamburgEppendorf, 20246 Hamburg, Germany.

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Nicolaus Kröger

8Department of Stem Cell Transplantation, University Medical Center HamburgEppendorf, 20246 Hamburg, Germany.

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Linos Vandekerckhove

9HIV Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital, B-9000 Ghent, Belgium.

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Jon Badiola

10Hematology Department, Virgen de las Nieves University Hospital, 18014 Granada, Spain.

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Alessandra Bandera

11San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, Italy.

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Kavita Raj

12Department of Haematology, King's College Hospital, London SE5 9RS, UK.

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Jan van Lunzen

11. Department of Medicine, Infectious Diseases Unit, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.

13ViiV Healthcare, Brentford, Middlesex TW8 9GS, UK.

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Gero Hütter

14Cellex, 01307 Dresden, Germany.

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Jürgen H. E. Kuball

15University Medical Center Utrecht, 3584 CX, Utrecht, Netherlands.

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Carolina Martinez-Laperche

16Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitarias Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain.

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Pascual Balsalobre

16Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitarias Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain.

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Mi Kwon

16Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitarias Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain.

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José L. Díez-Martín

16Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitarias Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain.

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Monique Nijhuis

15University Medical Center Utrecht, 3584 CX, Utrecht, Netherlands.

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Annemarie Wensing

15University Medical Center Utrecht, 3584 CX, Utrecht, Netherlands.

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Javier Martinez-Picado

4AIDS Research Institute IrsiCaixa, 08916 Badalona, Spain.

17UVic-UCC, 08500 Vic, Spain.

18ICREA, 08010 Barcelona, Spain.

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Julian Schulze zur Wiesch

11. Department of Medicine, Infectious Diseases Unit, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.

2DZIF Partner Site (German Center for Infection Research), Hamburg-Lübeck-Borstel-Riems Site, Hamburg, Germany.

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For correspondence: asier.saez-cirion@pasteur.fr julianszw@gmail.com

Asier Sáez-Cirión

3Institut Pasteur, HIV, Inflammation and Persistence, 75015 Paris, France.

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For correspondence: asier.saez-cirion@pasteur.fr julianszw@gmail.com

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Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

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