Research ArticleSepsis

BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis

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Science Translational Medicine  06 May 2020:
Vol. 12, Issue 542, eaax4517
DOI: 10.1126/scitranslmed.aax4517

Article Information

vol. 12 no. 542

Print ISSN: 
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  • Received for publication March 25, 2019
  • Resubmitted March 13, 2020
  • Accepted for publication April 16, 2020
  • .

Author Information

  1. Byron Brook1,
  2. Danny J. Harbeson1,
  3. Casey P. Shannon2,3,
  4. Bing Cai4,
  5. Daniel He1,2,3,
  6. Rym Ben-Othman4,
  7. Freddy Francis1,
  8. Joe Huang4,
  9. Natallia Varankovich4,
  10. Aaron Liu1,
  11. Winnie Bao4,
  12. Morten Bjerregaard-Andersen5,6,7,
  13. Frederik Schaltz-Buchholzer5,6,8,
  14. Lilica Sanca5,
  15. Christian N. Golding5,6,
  16. Kristina Lindberg Larsen5,6,
  17. Ofer Levy9,10,11,
  18. Beate Kampmann12,13,
  19. The EPIC Consortium*,
  20. Rusung Tan14,
  21. Adrian Charles14,
  22. James L. Wynn15,
  23. Frank Shann16,
  24. Peter Aaby5,
  25. Christine S. Benn5,6,8,
  26. Scott J. Tebbutt2,3,17,
  27. Tobias R. Kollmann1,4,18,, and
  28. Nelly Amenyogbe1,18,,
  1. 1Department of Experimental Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Room 10117, Vancouver, BC V5Z 1M9, Canada.
  2. 2PROOF Centre of Excellence, British Columbia, 10th floor, 1190 Hornby Street, Vancouver, BC V6Z 2K5, Canada.
  3. 3UBC Centre for Heart Lung Innovation, St. Paul’s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada.
  4. 4Department of Pediatrics, University of British Columbia, and BC Children’s Hospital, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada.
  5. 5Bandim Health Project, Indepth Network, Apartado 861, 1004 Bissau, Guinea-Bissau.
  6. 6Research Center for Vitamins and Vaccines (CVIVA), Statens Serum Institut (SSI), Artillerivej 5, 2300 Copenhagen S, Denmark.
  7. 7Department of Endocrinology, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark.
  8. 8OPEN, Institute of Clinical Research and Danish Institute for Advanced Science, University of Southern Denmark, and Odense University Hospital, J.B. Winsløws Vej, 5000 Odense C, Denmark.
  9. 9Precision Vaccines Program, Boston Children’s Hospital, Boston, MA 02115, USA.
  10. 10Harvard Medical School, Boston, MA 02115, USA.
  11. 11Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  12. 12Vaccines and Immunity Theme, Medical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, The Gambia.
  13. 13Vaccine Centre, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
  14. 14Department of Pathology, Sidra Medicine and Weill Cornell Medicine, Doha, Qatar.
  15. 15Department of Paediatrics and Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, P.O. Box 100296, Gainesville, FL 32610-0296, USA.
  16. 16Department of Paediatrics, University of Melbourne, Melbourne, VIC 3052, Australia.
  17. 17Department of Medicine, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
  18. 18Telethon Kids Institute, 100 Roberts Road, Subiaco, Western Australia 6008, Australia.
  1. Corresponding author. Email: n.akuvy{at} (N.A.); tkollm{at} (T.R.K.)
    • * The Expanded Program on Immunization (EPIC) Consortium collaborators and affiliations appear at the end of this paper.

    • These authors contributed equally to this work.


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