Research ArticleCORONAVIRUS
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- View ORCID ProfileTimothy P. Sheahan1,*,†,
- View ORCID ProfileAmy C. Sims1,*,‡,
- View ORCID ProfileShuntai Zhou2,
- View ORCID ProfileRachel L. Graham1,
- View ORCID ProfileAndrea J. Pruijssers3,
- Maria L. Agostini3,
- View ORCID ProfileSarah R. Leist1,
- View ORCID ProfileAlexandra Schäfer1,
- View ORCID ProfileKenneth H. Dinnon III1,4,
- View ORCID ProfileLaura J. Stevens3,
- James D. Chappell3,
- View ORCID ProfileXiaotao Lu3,
- View ORCID ProfileTia M. Hughes3,
- View ORCID ProfileAmelia S. George3,
- View ORCID ProfileCollin S. Hill2,
- View ORCID ProfileStephanie A. Montgomery5,
- Ariane J. Brown1,
- View ORCID ProfileGregory R. Bluemling6,7,
- Michael G. Natchus6,
- Manohar Saindane6,
- Alexander A. Kolykhalov6,7,
- View ORCID ProfileGeorge Painter6,7,8,
- View ORCID ProfileJennifer Harcourt9,
- View ORCID ProfileAzaibi Tamin9,
- Natalie J. Thornburg9,
- View ORCID ProfileRonald Swanstrom2,10,
- View ORCID ProfileMark R. Denison3 and
- View ORCID ProfileRalph S. Baric1,4,†
- 1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- 2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- 3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
- 4Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- 5Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
- 6Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.
- 7Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.
- 8Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA 30322, USA.
- 9Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
- 10Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- ↵†Corresponding author. Email: sheahan{at}email.unc.edu (T.P.S.); rbaric{at}email.unc.edu (R.S.B.)
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Science Translational Medicine 29 Apr 2020:
Vol. 12, Issue 541, eabb5883
DOI: 10.1126/scitranslmed.abb5883
Vol. 12, Issue 541, eabb5883
DOI: 10.1126/scitranslmed.abb5883
Timothy P. Sheahan
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Amy C. Sims
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Shuntai Zhou
2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Rachel L. Graham
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Andrea J. Pruijssers
3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Maria L. Agostini
3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Sarah R. Leist
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Alexandra Schäfer
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kenneth H. Dinnon III
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
4Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Laura J. Stevens
3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
James D. Chappell
3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Xiaotao Lu
3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Tia M. Hughes
3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Amelia S. George
3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Collin S. Hill
2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Stephanie A. Montgomery
5Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Ariane J. Brown
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Gregory R. Bluemling
6Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.
7Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.
Michael G. Natchus
6Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.
Manohar Saindane
6Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.
Alexander A. Kolykhalov
6Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.
7Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.
George Painter
6Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.
7Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.
8Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA 30322, USA.
Jennifer Harcourt
9Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Azaibi Tamin
9Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Natalie J. Thornburg
9Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Ronald Swanstrom
2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
10Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Mark R. Denison
3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Ralph S. Baric
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
4Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
