Research ArticleCORONAVIRUS

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

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Science Translational Medicine  29 Apr 2020:
Vol. 12, Issue 541, eabb5883
DOI: 10.1126/scitranslmed.abb5883

Article Information

vol. 12 no. 541

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 5, 2020
  • Accepted for publication April 3, 2020
  • .

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Author Information

  1. Timothy P. Sheahan1,*,,
  2. Amy C. Sims1,*,,
  3. Shuntai Zhou2,
  4. Rachel L. Graham1,
  5. Andrea J. Pruijssers3,
  6. Maria L. Agostini3,
  7. Sarah R. Leist1,
  8. Alexandra Schäfer1,
  9. Kenneth H. Dinnon III1,4,
  10. Laura J. Stevens3,
  11. James D. Chappell3,
  12. Xiaotao Lu3,
  13. Tia M. Hughes3,
  14. Amelia S. George3,
  15. Collin S. Hill2,
  16. Stephanie A. Montgomery5,
  17. Ariane J. Brown1,
  18. Gregory R. Bluemling6,7,
  19. Michael G. Natchus6,
  20. Manohar Saindane6,
  21. Alexander A. Kolykhalov6,7,
  22. George Painter6,7,8,
  23. Jennifer Harcourt9,
  24. Azaibi Tamin9,
  25. Natalie J. Thornburg9,
  26. Ronald Swanstrom2,10,
  27. Mark R. Denison3 and
  28. Ralph S. Baric1,4,
  1. 1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  2. 2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  3. 3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  4. 4Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  5. 5Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
  6. 6Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.
  7. 7Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.
  8. 8Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA 30322, USA.
  9. 9Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  10. 10Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  1. Corresponding author. Email: sheahan{at}email.unc.edu (T.P.S.); rbaric{at}email.unc.edu (R.S.B.)
  • * These authors contributed equally to this work.

  • Present address: National Security Division, Pacific Northwest National Laboratory, Chemical and Biological Signature Sciences, Richland, WA 99352, USA.

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Apr 2020410316472733173
May 20203434148210608
Jun 202088149523605
Jul 2020107110332476
Aug 20208862601644
Sep 20208572101369
Oct 202012566501536
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