Research ArticleInflammation

An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products

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Science Translational Medicine  22 Apr 2020:
Vol. 12, Issue 540, eaay0605
DOI: 10.1126/scitranslmed.aay0605

Tamping down type-2 inflammation

Type-2 immunity in allergy and asthma is driven by nonredundant pathways, sometimes making therapeutic targeting difficult. De los Reyes Jiménez et al. investigated whether factors from a known mediator of type-2 immunity, the helminth Heligmosomoides polygyrus bakeri, could have added beneficial anti-inflammatory effects. They found that helminth larvae modulated eicosanoids in human macrophages and granulocytes. Both the larvae and the helminth protein glutamate dehydrogenase alleviated inflammation in a house dust mite model of asthma. These results suggest that helminth products have the potential to broadly modulate pathways in type-2 immune diseases.

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