Research ArticleMyocardial Infarction

Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats

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Science Translational Medicine  22 Apr 2020:
Vol. 12, Issue 540, eaaw3172
DOI: 10.1126/scitranslmed.aaw3172

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Curbing cardiac cell death

Cell death resulting from myocardial infarction contributes to cardiac dysfunction and pathological remodeling. Wang et al. found that blocking tumor necrosis factor–related apoptosis-inducing ligand (TRAIL), a ligand of death receptor 5 (DR5), reduced inflammation and improved cardiac function after myocardial infarction in multiple animal models. Treating rodents, pigs, and monkeys with a soluble DR5 fusion protein within 2 hours after inducing ischemia reduced recruitment of myeloid cells to injured heart tissue and blunted cell death. TRAIL blockade could offer potential cardiac protection in the setting of myocardial infarction.

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