Research ArticleParkinson’s Disease

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

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Science Translational Medicine  22 Apr 2020:
Vol. 12, Issue 540, eaav0820
DOI: 10.1126/scitranslmed.aav0820

Article Information

vol. 12 no. 540

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 13, 2018
  • Accepted for publication July 22, 2019
  • .

Author Information

  1. Marco A. S. Baptista1,*,
  2. Kalpana Merchant2,
  3. Ted Barrett3,
  4. Sakshi Bhargava4,
  5. Dianne K. Bryce5,
  6. J. Michael Ellis5,,
  7. Anthony A. Estrada6,,
  8. Matthew J. Fell5,
  9. Brian K. Fiske1,
  10. Reina N. Fuji6,
  11. Paul Galatsis4,§,
  12. Anastasia G. Henry7,
  13. Sue Hill5,
  14. Warren Hirst4,||,
  15. Christopher Houle4,
  16. Matthew E. Kennedy5,
  17. Xingrong Liu6,
  18. Matthew L. Maddess5,
  19. Carrie Markgraf5,,
  20. Hong Mei5,
  21. William A. Meier8,
  22. Elie Needle4,
  23. Stephen Ploch8,
  24. Christopher Royer3,
  25. Karin Rudolph3,
  26. Alok K. Sharma8,
  27. Antonia Stepan4,
  28. Stefan Steyn4,
  29. Craig Trost8,
  30. Zhizhang Yin5,
  31. Hongshi Yu5,
  32. Xiang Wang7 and
  33. Todd B. Sherer1
  1. 1The Michael J. Fox Foundation for Parkinson’s Research, Grand Central Station, P.O. Box 4777, New York, NY 10001, USA.
  2. 2Northwestern University School of Medicine, Chicago, IL 60611, USA.
  3. 3Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.
  4. 4Pfizer Inc., Neuroscience Research Unit, Cambridge, MA 02139, USA.
  5. 5Merck Research Laboratories, Early Discovery Neuroscience, Boston, MA 02115, USA.
  6. 6Genentech, Inc., South San Francisco, CA 94080, USA.
  7. 7Denali Therapeutics, South San Francisco, CA 94080, USA.
  8. 8Covance Laboratories, Inc., Madison, WI 53704, USA.
  1. *Corresponding author. Email: mbaptista{at}michaeljfox.org
  • Present address: Bristol Myers Squibb, Cambridge, MA 02140, USA.

  • Present address: Denali Therapeutics, South San Francisco, CA 94080, USA.

  • § Present address: Enko, Inc, Woburn, MA 01801, USA.

  • || Present address: Biogen, Cambridge, MA 02142, USA.

  • Deceased.

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