22 April 2020
Vol 12, Issue 540

About The Cover

Cover image expansion

ONLINE COVER Breathing Easy. Young children and infants, such as the babies pictured here, are susceptible to respiratory syncytial virus (RSV). Although most infections are mild, some may require hospitalization. To better understand immune responses associated with severe RSV infections, Heinonen et al. compared samples from young children infected with RSV who were managed as outpatients (mild infections) to those who were hospitalized (severe infections). Samples from mild infections harbored higher viral loads and indicated a strong innate immune response. A vaccine or therapeutic that recapitulates the helpful immune responses observed during mild infections could one day increase the number of young children that sniffle rather than suffer from RSV. [CREDIT: YAY MEDIA AS/ALAMY]