Contents
22 April 2020
Vol 12, Issue 540
Vol 12, Issue 540
Research Articles
- Immune profiles provide insights into respiratory syncytial virus disease severity in young children
The mild RSV disease phenotype is driven by robust IFN expression, adequate monocyte activation, and high viral loads.
- An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products
A helminth larval extract and its component Hpb glutamate dehydrogenase induce an anti-inflammatory mediator switch to suppress type-2 inflammation.
- Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats
TRAIL blockade limits cardiac cell death and reduces inflammation to improve cardiac function after myocardial infarction in rats, pigs, and monkeys.
- Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice
Patient stem cell–derived β cells corrected for a diabetes-causing variant in WFS1 restore glucose homeostasis when transplanted into diabetic mice.
- LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits
Morphological changes in the lungs of macaques induced by several different LRRK2 inhibitors are reversible and do not lead to lung deficits.
Perspective
- The evidence landscape in precision medicine
Evidence landscapes can help to coordinate research and address challenges in implementing precision medicine.
Editors' Choice
- Glymphatics rapidly clear nanoparticles
The glymphatics system of the brain rapidly clears organic nanoparticles commonly used for brain drug delivery.
- Can cell therapies halt cytokine storm in severe COVID-19 patients?
A pilot study of COVID-19 patients treated with mesenchymal stem cells demonstrates safety.
- Casting the development of iron-recycling macrophages
Interleukin-33 signaling directs the maturation of iron-metabolizing macrophages.
Erratum
Letter
About The Cover
ONLINE COVER Breathing Easy. Young children and infants, such as the babies pictured here, are susceptible to respiratory syncytial virus (RSV). Although most infections are mild, some may require hospitalization. To better understand immune responses associated with severe RSV infections, Heinonen et al. compared samples from young children infected with RSV who were managed as outpatients (mild infections) to those who were hospitalized (severe infections). Samples from mild infections harbored higher viral loads and indicated a strong innate immune response. A vaccine or therapeutic that recapitulates the helpful immune responses observed during mild infections could one day increase the number of young children that sniffle rather than suffer from RSV. [CREDIT: YAY MEDIA AS/ALAMY]
