Contents
15 April 2020
Vol 12, Issue 539
Vol 12, Issue 539
Research Articles
- LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling
LC3-associated phagocytosis is a protective mechanism against inflammation, with antifibrogenic properties in the liver.
- Inhibition of TET1 prevents the development of osteoarthritis and reveals the 5hmC landscape that orchestrates pathogenesis
Modulating cytosine hydroxymethylation by inhibiting TET1 activity prevents osteoarthritis in mice.
- Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans
Interleukin 17 and senescent cells regulate fibrosis in the foreign body response to synthetic material implants.
- Early delivery and prolonged treatment with nimodipine prevents the development of spasticity after spinal cord injury in mice
Prolonged treatment with nimodipine soon after spinal cord injury in mice prevents spasticity by blocking L-type calcium channels CaV1.3.
- Identification of tetranectin-targeting monoclonal antibodies to treat potentially lethal sepsis
An antibody strategy prevents harmful TN/HMGB1 interaction and resultant macrophage pyroptosis and immunosuppression in sepsis.
Focus
- Breaking the bond between tetranectin and HMGB1 in sepsis
The interaction between tetranectin and high-mobility group box-1 may be manipulated via monoclonal antibodies to improve survival in sepsis (Chen et al., same issue).
Editors' Choice
- From GWAS to GEMMs: Sestrin1 and cholesterol biosynthesis
Sestrin1 regulates hepatic cholesterol synthesis and circulating lipid concentrations.
- The sticky culprit: Platelets in cystic fibrosis
Platelets trigger lung inflammation in cystic fibrosis.
- Improving cancer combination therapy by timing drug administration
Sequential treatment provides therapeutic benefit in pancreatic cancer models.
About The Cover
ONLINE COVER A Victory LAP for Liver Injury? Chronic liver injury is associated with systemic inflammation and immune dysfunction that can lead to organ failure. This image shows LC3 phagosomes (green) in monocytes from a patient with liver injury. Wan et al. found that LC3-associated phagocytosis (LAP), a form of autophagy with anti-inflammatory properties, was increased in monocytes from patients with chronic liver injury. LAP inhibition exacerbated inflammation and liver fibrosis in a mouse model of liver injury, whereas enhancing LAP had liver-protective effects. Results suggest that boosting LAP activation might have therapeutic potential. [CREDIT: WAN ET AL./SCIENCE TRANSLATIONAL MEDICINE]
