15 April 2020
Vol 12, Issue 539

About The Cover

Cover image expansion

ONLINE COVER A Victory LAP for Liver Injury? Chronic liver injury is associated with systemic inflammation and immune dysfunction that can lead to organ failure. This image shows LC3 phagosomes (green) in monocytes from a patient with liver injury. Wan et al. found that LC3-associated phagocytosis (LAP), a form of autophagy with anti-inflammatory properties, was increased in monocytes from patients with chronic liver injury. LAP inhibition exacerbated inflammation and liver fibrosis in a mouse model of liver injury, whereas enhancing LAP had liver-protective effects. Results suggest that boosting LAP activation might have therapeutic potential. [CREDIT: WAN ET AL./SCIENCE TRANSLATIONAL MEDICINE]