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The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability

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Science Translational Medicine  08 Apr 2020:
Vol. 12, Issue 538, eaaz8264
DOI: 10.1126/scitranslmed.aaz8264

Article Information

vol. 12 no. 538

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 12, 2019
  • Accepted for publication March 9, 2020
  • .

Author Information

  1. Sara Mirali1,2,
  2. Aaron Botham1,3,
  3. Veronique Voisin4,
  4. Changjiang Xu4,
  5. Jonathan St-Germain1,
  6. David Sharon1,
  7. Fieke W. Hoff5,6,
  8. Yihua Qiu6,
  9. Rose Hurren1,
  10. Marcela Gronda1,
  11. Yulia Jitkova1,
  12. Boaz Nachmias1,
  13. Neil MacLean1,
  14. Xiaoming Wang1,
  15. Andrea Arruda1,
  16. Mark D. Minden1,2,3,
  17. Terzah M. Horton7,
  18. Steven M. Kornblau6,
  19. Steven M. Chan1,3,
  20. Gary D. Bader4,8,
  21. Brian Raught1,3 and
  22. Aaron D. Schimmer1,2,3,*
  1. 1Princess Margaret Cancer Centre, Toronto, Ontario M5G 1L7, Canada.
  2. 2Institute of Medical Science, University of Toronto, Toronto M5S 1A8, Ontario, Canada.
  3. 3Department of Medical Biophysics, University of Toronto, Toronto M5G 1L7, Ontario, Canada.
  4. 4Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada.
  5. 5Department of Pediatric Oncology/Hematology, University Medical Center Groningen, Groningen 9700 RB, Netherlands.
  6. 6Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  7. 7Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX 77030, USA.
  8. 8Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Ontario, Canada.
  1. *Corresponding author. Email: aaron.schimmer{at}uhn.ca

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