Research ArticleCancer

The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability

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Science Translational Medicine  08 Apr 2020:
Vol. 12, Issue 538, eaaz8264
DOI: 10.1126/scitranslmed.aaz8264

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Cutting leukemia’s energy supply

Neurolysin is a protein that is found in the mitochondria and secreted into the circulation. It is known to help regulate physiological functions such as blood pressure but is not essential for survival in mice. Mirali et al. discovered that neurolysin is frequently overexpressed in acute myeloid leukemia. The authors examined the underlying mechanism and identified the role of neurolysin in the formation of respiratory chain supercomplexes in the mitochondria. They also showed that inhibition of neurolysin is selectively toxic to leukemic cells without affecting normal hematopoietic cells and demonstrated the effectiveness of this approach in mouse models of leukemia.

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