Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates

Chia-Han Chiang; Sang Min Won; Amy L. Orsborn; Ki Jun Yu; Michael Trumpis; Brinnae Bent; Charles Wang; Yeguang Xue; Seunghwan Min; Virginia Woods; Chunxiu Yu; Bong Hoon Kim; Sung Bong Kim; Rizwan Huq; Jinghua Li; Kyung Jin Seo; Flavia Vitale; Andrew Richardson; Hui Fang; Yonggang Huang; Kenneth Shepard; Bijan Pesaran; John A. Rogers; Jonathan Viventi

doi:10.1126/scitranslmed.aay4682

Research ArticleNEUROTECHNOLOGY

Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates

View ORCID ProfileChia-Han Chiang¹,*,†,
View ORCID ProfileSang Min Won²,*,
Amy L. Orsborn³,⁴,⁵,*,
Ki Jun Yu⁶,*,
View ORCID ProfileMichael Trumpis¹,
Brinnae Bent¹,
Charles Wang¹,
View ORCID ProfileYeguang Xue⁷,⁸,
Seunghwan Min⁹,
View ORCID ProfileVirginia Woods¹,
Chunxiu Yu¹,¹⁰,
View ORCID ProfileBong Hoon Kim¹¹,¹²,
View ORCID ProfileSung Bong Kim¹³,
View ORCID ProfileRizwan Huq¹⁴,
Jinghua Li¹³,¹⁵,¹⁶,
View ORCID ProfileKyung Jin Seo¹⁷,
View ORCID ProfileFlavia Vitale¹⁸,¹⁹,
View ORCID ProfileAndrew Richardson²⁰,
View ORCID ProfileHui Fang¹⁷,
View ORCID ProfileYonggang Huang⁷,⁸,¹³,²¹,
View ORCID ProfileKenneth Shepard ¹⁴,²²,
View ORCID ProfileBijan Pesaran³,²³,†,
View ORCID ProfileJohn A. Rogers⁷,⁸,¹³,¹⁵,²¹,²⁴,²⁵,²⁶,²⁷,† and
View ORCID ProfileJonathan Viventi ¹,²⁸,²⁹,†

¹Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
²Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
³Center for Neural Science, New York University, New York, NY 10003, USA.
⁴Department of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA.
⁵Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
⁶School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, Republic of Korea.
⁷Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
⁸Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.
⁹Department of Electrical and Computer Engineering, University of Wisconsin–Madison, Madison, WI 53706, USA.
¹⁰Department of Biological Science, Michigan Technological University, Houghton, MI 49931, USA.
¹¹Department of Organic Materials and Fiber Engineering, Soongsil University, Seoul 06978, Republic of Korea.
¹²Department of Information Communication, Materials, and Chemistry Convergence Technology, Soongsil University, Seoul 06978, Republic of Korea.
¹³Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
¹⁴Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.
¹⁵Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
¹⁶Department of Materials Science and Engineering, Center for Chronic Brain Injury, The Ohio State University, Columbus, OH 43210, USA.
¹⁷Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115, USA.
¹⁸Department of Neurology, Department of Bioengineering, Department of Physical Medicine & Rehabilitation, Center for Neuroengineering and Therapeutics, University of Pennsylvania, PA 19104, USA.
¹⁹Center of Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.
²⁰Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
²¹Center for Bio-integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
²²Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
²³Department of Neurology, NYU Langone Health, New York, NY 10016, USA.
²⁴Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA.
²⁵Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
²⁶Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
²⁷Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
²⁸Department of Neurobiology, Duke University, Durham, NC 27708, USA.
²⁹Department of Neurosurgery, Duke University, Durham, NC 27708, USA.

↵†Corresponding author. Email: j.viventi{at}duke.edu (J.V.); jrogers{at}northwestern.edu (J.A.R.); bijan{at}nyu.edu(B.P.); kenchiangch{at}gmail.com (C.-H.C.)

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Translational Medicine 08 Apr 2020:
Vol. 12, Issue 538, eaay4682
DOI: 10.1126/scitranslmed.aay4682

Chia-Han Chiang

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Chia-Han Chiang
For correspondence: j.viventi@duke.edu jrogers@northwestern.edu bijan@nyu.edu kenchiangch@gmail.com

Sang Min Won

2Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sang Min Won

Amy L. Orsborn

3Center for Neural Science, New York University, New York, NY 10003, USA.

4Department of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA.

5Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ki Jun Yu

6School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, Republic of Korea.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Michael Trumpis

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Michael Trumpis

Brinnae Bent

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Charles Wang

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yeguang Xue

7Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

8Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yeguang Xue

Seunghwan Min

9Department of Electrical and Computer Engineering, University of Wisconsin–Madison, Madison, WI 53706, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Virginia Woods

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Virginia Woods

Chunxiu Yu

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

10Department of Biological Science, Michigan Technological University, Houghton, MI 49931, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Bong Hoon Kim

11Department of Organic Materials and Fiber Engineering, Soongsil University, Seoul 06978, Republic of Korea.

12Department of Information Communication, Materials, and Chemistry Convergence Technology, Soongsil University, Seoul 06978, Republic of Korea.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Bong Hoon Kim

Sung Bong Kim

13Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sung Bong Kim

Rizwan Huq

14Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Rizwan Huq

Jinghua Li

13Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

15Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

16Department of Materials Science and Engineering, Center for Chronic Brain Injury, The Ohio State University, Columbus, OH 43210, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kyung Jin Seo

17Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kyung Jin Seo

Flavia Vitale

18Department of Neurology, Department of Bioengineering, Department of Physical Medicine & Rehabilitation, Center for Neuroengineering and Therapeutics, University of Pennsylvania, PA 19104, USA.

19Center of Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Flavia Vitale

Andrew Richardson

20Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Andrew Richardson

Hui Fang

17Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Hui Fang

Yonggang Huang

7Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

8Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

13Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

21Center for Bio-integrated Electronics, Northwestern University, Evanston, IL 60208, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yonggang Huang

Kenneth Shepard

14Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.

22Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kenneth Shepard

Bijan Pesaran

3Center for Neural Science, New York University, New York, NY 10003, USA.

23Department of Neurology, NYU Langone Health, New York, NY 10016, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Bijan Pesaran
For correspondence: j.viventi@duke.edu jrogers@northwestern.edu bijan@nyu.edu kenchiangch@gmail.com

John A. Rogers

7Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

8Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

13Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

15Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

21Center for Bio-integrated Electronics, Northwestern University, Evanston, IL 60208, USA.

24Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA.

25Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

26Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.

27Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for John A. Rogers
For correspondence: j.viventi@duke.edu jrogers@northwestern.edu bijan@nyu.edu kenchiangch@gmail.com

Jonathan Viventi

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

28Department of Neurobiology, Duke University, Durham, NC 27708, USA.

29Department of Neurosurgery, Duke University, Durham, NC 27708, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jonathan Viventi
For correspondence: j.viventi@duke.edu jrogers@northwestern.edu bijan@nyu.edu kenchiangch@gmail.com

Article
Figures & Data
Info & Metrics
eLetters
PDF

Log in to view PDF

via AAAS login

AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.

Become an AAAS Member
Activate your Account
Purchase Access to Other Journals in the Science Family
Account Help

Log in through your institution

More options

Purchase digital access to this article

Download and print this article for your personal scholarly, research, and educational use.

Purchase this issue in print

Buy a single issue of Science for just $15 USD.

View Full Text

Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates

Log in to view PDF

Log in through your institution

Log in through your institution

More options

Science Translational Medicine

Article Tools