Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates

Chia-Han Chiang; Sang Min Won; Amy L. Orsborn; Ki Jun Yu; Michael Trumpis; Brinnae Bent; Charles Wang; Yeguang Xue; Seunghwan Min; Virginia Woods; Chunxiu Yu; Bong Hoon Kim; Sung Bong Kim; Rizwan Huq; Jinghua Li; Kyung Jin Seo; Flavia Vitale; Andrew Richardson; Hui Fang; Yonggang Huang; Kenneth Shepard; Bijan Pesaran; John A. Rogers; Jonathan Viventi

doi:10.1126/scitranslmed.aay4682

Research ArticleNEUROTECHNOLOGY

Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates

View ORCID ProfileChia-Han Chiang¹,*,†,
View ORCID ProfileSang Min Won²,*,
Amy L. Orsborn³,⁴,⁵,*,
Ki Jun Yu⁶,*,
View ORCID ProfileMichael Trumpis¹,
Brinnae Bent¹,
Charles Wang¹,
View ORCID ProfileYeguang Xue⁷,⁸,
Seunghwan Min⁹,
View ORCID ProfileVirginia Woods¹,
Chunxiu Yu¹,¹⁰,
View ORCID ProfileBong Hoon Kim¹¹,¹²,
View ORCID ProfileSung Bong Kim¹³,
View ORCID ProfileRizwan Huq¹⁴,
Jinghua Li¹³,¹⁵,¹⁶,
View ORCID ProfileKyung Jin Seo¹⁷,
View ORCID ProfileFlavia Vitale¹⁸,¹⁹,
View ORCID ProfileAndrew Richardson²⁰,
View ORCID ProfileHui Fang¹⁷,
View ORCID ProfileYonggang Huang⁷,⁸,¹³,²¹,
View ORCID ProfileKenneth Shepard ¹⁴,²²,
View ORCID ProfileBijan Pesaran³,²³,†,
View ORCID ProfileJohn A. Rogers⁷,⁸,¹³,¹⁵,²¹,²⁴,²⁵,²⁶,²⁷,† and
View ORCID ProfileJonathan Viventi ¹,²⁸,²⁹,†

¹Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
²Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
³Center for Neural Science, New York University, New York, NY 10003, USA.
⁴Department of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA.
⁵Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
⁶School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, Republic of Korea.
⁷Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
⁸Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.
⁹Department of Electrical and Computer Engineering, University of Wisconsin–Madison, Madison, WI 53706, USA.
¹⁰Department of Biological Science, Michigan Technological University, Houghton, MI 49931, USA.
¹¹Department of Organic Materials and Fiber Engineering, Soongsil University, Seoul 06978, Republic of Korea.
¹²Department of Information Communication, Materials, and Chemistry Convergence Technology, Soongsil University, Seoul 06978, Republic of Korea.
¹³Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
¹⁴Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.
¹⁵Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
¹⁶Department of Materials Science and Engineering, Center for Chronic Brain Injury, The Ohio State University, Columbus, OH 43210, USA.
¹⁷Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115, USA.
¹⁸Department of Neurology, Department of Bioengineering, Department of Physical Medicine & Rehabilitation, Center for Neuroengineering and Therapeutics, University of Pennsylvania, PA 19104, USA.
¹⁹Center of Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.
²⁰Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
²¹Center for Bio-integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
²²Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
²³Department of Neurology, NYU Langone Health, New York, NY 10016, USA.
²⁴Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA.
²⁵Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
²⁶Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
²⁷Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
²⁸Department of Neurobiology, Duke University, Durham, NC 27708, USA.
²⁹Department of Neurosurgery, Duke University, Durham, NC 27708, USA.

↵†Corresponding author. Email: j.viventi{at}duke.edu (J.V.); jrogers{at}northwestern.edu (J.A.R.); bijan{at}nyu.edu(B.P.); kenchiangch{at}gmail.com (C.-H.C.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 08 Apr 2020:
Vol. 12, Issue 538, eaay4682
DOI: 10.1126/scitranslmed.aay4682

Chia-Han Chiang

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

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For correspondence: j.viventi@duke.edu jrogers@northwestern.edu bijan@nyu.edu kenchiangch@gmail.com

Sang Min Won

2Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.

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Amy L. Orsborn

3Center for Neural Science, New York University, New York, NY 10003, USA.

4Department of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA.

5Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

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Ki Jun Yu

6School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, Republic of Korea.

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Michael Trumpis

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

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Brinnae Bent

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

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Charles Wang

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

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Yeguang Xue

7Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

8Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

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Seunghwan Min

9Department of Electrical and Computer Engineering, University of Wisconsin–Madison, Madison, WI 53706, USA.

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Virginia Woods

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

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Chunxiu Yu

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

10Department of Biological Science, Michigan Technological University, Houghton, MI 49931, USA.

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Bong Hoon Kim

11Department of Organic Materials and Fiber Engineering, Soongsil University, Seoul 06978, Republic of Korea.

12Department of Information Communication, Materials, and Chemistry Convergence Technology, Soongsil University, Seoul 06978, Republic of Korea.

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Sung Bong Kim

13Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

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Rizwan Huq

14Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.

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Jinghua Li

13Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

15Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

16Department of Materials Science and Engineering, Center for Chronic Brain Injury, The Ohio State University, Columbus, OH 43210, USA.

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Kyung Jin Seo

17Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115, USA.

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Flavia Vitale

18Department of Neurology, Department of Bioengineering, Department of Physical Medicine & Rehabilitation, Center for Neuroengineering and Therapeutics, University of Pennsylvania, PA 19104, USA.

19Center of Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.

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Andrew Richardson

20Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Hui Fang

17Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115, USA.

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Yonggang Huang

7Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

8Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

13Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

21Center for Bio-integrated Electronics, Northwestern University, Evanston, IL 60208, USA.

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Kenneth Shepard

14Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.

22Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

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Bijan Pesaran

3Center for Neural Science, New York University, New York, NY 10003, USA.

23Department of Neurology, NYU Langone Health, New York, NY 10016, USA.

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For correspondence: j.viventi@duke.edu jrogers@northwestern.edu bijan@nyu.edu kenchiangch@gmail.com

John A. Rogers

7Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

8Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

13Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

15Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

21Center for Bio-integrated Electronics, Northwestern University, Evanston, IL 60208, USA.

24Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA.

25Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

26Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.

27Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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For correspondence: j.viventi@duke.edu jrogers@northwestern.edu bijan@nyu.edu kenchiangch@gmail.com

Jonathan Viventi

1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

28Department of Neurobiology, Duke University, Durham, NC 27708, USA.

29Department of Neurosurgery, Duke University, Durham, NC 27708, USA.

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For correspondence: j.viventi@duke.edu jrogers@northwestern.edu bijan@nyu.edu kenchiangch@gmail.com

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Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates

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