Contents

08 April 2020
Vol 12, Issue 538

About The Cover

Cover image expansion

ONLINE COVER Patch Perfect. This scanning electron microscopy image shows synthetic cells (red) within a cardiac patch. Huang et al. constructed patches embedding decellularized porcine heart tissue scaffolds with synthetic cells, which were composed of polymeric microparticles encapsulating factors secreted by human cardiac stromal cells. Applying these acellular patches to rodent hearts after myocardial infarction reduced scar size, increased blood vessel formation in the infarct area, and improved cardiac function. Patches remained viable after cryopreservation and were also safely applied to pig hearts. Acellular cardiac patches could provide an off-the-shelf treatment to support cardiac remodeling after infarction. [CREDIT: HUANG ET AL./SCIENCE TRANSLATIONAL MEDICINE]