Contents
08 April 2020
Vol 12, Issue 538
Vol 12, Issue 538
Research Articles
- An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs
Acellular patches embedded with encapsulated cell-secreted factors improve cardiac repair after acute myocardial infarction in rodents and pigs.
- The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability
Targeting mitochondrial supercomplex assembly impairs metabolism and selectively targets leukemic cells.
- Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis
HIF-1 dictates effector function of infiltrating T cells in lupus, causing tissue damage that can be abrogated by its blockade in murine models.
- IL-6 blockade reverses bone marrow failure induced by human acute myeloid leukemia
Acute myeloid leukemia inhibits normal erythroid differentiation through paracrine effects of IL-6.
- Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates
A scalable neural interface technology projected to last at least 6 years in the body samples over a thousand brain sites using flexible electronics.
Editors' Choice
- Nanoreactors get tumor cells hot (but not bothered)
A near-infrared light-responsive nanoreactor enables heat ablation of tumors while preventing the inflammatory response to this approach.
- Predicting donor heart function in a heartbeat
Machine learning methods can assess contractility of donor hearts maintained via ex vivo perfusion to predict posttransplant cardiac function.
- Immunomodulatory stromal cell interactions in the eye
Single-cell sequencing of eye stroma reveals cell-cell interactions essential for suppressing ocular inflammation.
About The Cover
ONLINE COVER Patch Perfect. This scanning electron microscopy image shows synthetic cells (red) within a cardiac patch. Huang et al. constructed patches embedding decellularized porcine heart tissue scaffolds with synthetic cells, which were composed of polymeric microparticles encapsulating factors secreted by human cardiac stromal cells. Applying these acellular patches to rodent hearts after myocardial infarction reduced scar size, increased blood vessel formation in the infarct area, and improved cardiac function. Patches remained viable after cryopreservation and were also safely applied to pig hearts. Acellular cardiac patches could provide an off-the-shelf treatment to support cardiac remodeling after infarction. [CREDIT: HUANG ET AL./SCIENCE TRANSLATIONAL MEDICINE]
