Research ArticleCancer

Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling

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Science Translational Medicine  01 Apr 2020:
Vol. 12, Issue 537, eaaw0262
DOI: 10.1126/scitranslmed.aaw0262

Noninvasive nanoparticles for lung cancer

Previously developed nanoparticle technology has been shown to detect the hallmark protease activity of many cancers, amplifying it into a urinary readout. Now, Kirkpatrick et al. optimize protease activity–based nanosensors for the detection of lung cancer. Intratracheal instillation of nanosensors enabled detection of localized lung adenocarcinoma in two immunocompetent, autochthonous mouse models. The sensors distinguished between lung cancer and lung inflammation, and did not detect protease activity in a colorectal cancer xenograft model. Further work will need to confirm the approach for human lung cancer and other lung cancer subtypes and to formulate the nanosensors for intrapulmonary delivery in patients.

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