Contents
01 April 2020
Vol 12, Issue 537
Vol 12, Issue 537
Research Articles
- Spontaneous reversal of stenosis in tissue-engineered vascular grafts
Computational modeling and ovine data reveal spontaneous reversal of early tissue-engineered vascular graft stenosis, with clinical implications.
- Control of brain tumor growth by reactivating myeloid cells with niacin
By rejuvenating the deficient activity of myeloid cells in glioblastoma, niacin improves the treatment of otherwise incurable brain tumors.
- A durable protective immune response to wild-type measles virus infection of macaques is due to viral replication and spread in lymphoid tissues
Wild-type measles virus replicates better in immune cells and induces more durable antibody responses in macaques than the live-attenuated measles virus vaccine.
- Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling
Intrapulmonary protease-sensitive nanoparticles detect lung cancer as a urinary readout in two genetically engineered mouse models.
- PBX1 expression in uterine natural killer cells drives fetal growth
A subset of uterine natural killer cells promotes fetal growth through regulation of growth-promoting factors by PBX1.
- Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer
Low–tumor mutational burden prostate tumors express neoantigens that elicit T cell responses associated with favorable clinical outcomes to ipilimumab.
Editors' Choice
- Location, location, location: A tubal neighborhood unfriendly to implantation
Reduced adrenomedullin secretion by tubal epithelial cells results in increased macrophage function and increased susceptibility to ectopic pregnancy.
- The neural circuit model in psychiatry pays off
Noninvasive brain stimulation in depressed patients can be used to target different neural circuits, improving different symptoms.
- Macrophages make you stronger
Macrophage-derived meteorin-like promotes skeletal muscle repair.
About The Cover
ONLINE COVER Navigating the Narrows. These pseudocolored three-dimensional angiograms show a tissue-engineered vascular graft at 6 weeks (left) and at 1 year (right) after implantation in a lamb. Upon observing unexpected graft narrowing (stenosis) months after surgery, Drews et al. halted a clinical study implanting polymer grafts seeded with bone marrow–derived cells to correct single-ventricle cardiac anomalies in human pediatric patients. Computational modeling and experiments in lambs demonstrated similar stenosis 6 weeks after graft implantation (left angiogram in image). However, graft stenosis resolved without surgical intervention within 1 year after implantation in lambs (right angiogram in image). Results suggest grafts may spontaneously resolve stenosis during remodeling, supporting further use of tissue-engineered vascular grafts for cardiac applications. [CREDIT: KEJAL SHAH]
