Research ArticleCancer
Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells
- View ORCID ProfileAnna Julie Peired1,2,
- Giulia Antonelli1,2,
- Maria Lucia Angelotti1,2,
- View ORCID ProfileMarco Allinovi1,2,3,
- View ORCID ProfileFrancesco Guzzi2,
- View ORCID ProfileAlessandro Sisti4,
- Roberto Semeraro2,
- Carolina Conte1,2,
- Benedetta Mazzinghi4,
- Sara Nardi4,
- View ORCID ProfileMaria Elena Melica1,2,
- View ORCID ProfileLetizia De Chiara4,
- Elena Lazzeri1,2,
- Laura Lasagni1,2,
- Tiziano Lottini5,
- View ORCID ProfileSamuela Landini2,
- Sabrina Giglio2,
- View ORCID ProfileAndrea Mari6,
- View ORCID ProfileFabrizio Di Maida6,
- View ORCID ProfileAlessandro Antonelli7,
- Francesco Porpiglia8,
- Riccardo Schiavina9,
- Vincenzo Ficarra10,
- Davide Facchiano6,
- Mauro Gacci6,
- Sergio Serni6,
- Marco Carini6,
- George J. Netto11,
- View ORCID ProfileRosa Maria Roperto4,
- Alberto Magi2,
- View ORCID ProfileChristian Fynbo Christiansen12,
- Mario Rotondi13,
- View ORCID ProfileHelen Liapis14,*,
- View ORCID ProfileHans-Joachim Anders15,
- Andrea Minervini6,
- View ORCID ProfileMaria Rosaria Raspollini16 and
- View ORCID ProfilePaola Romagnani1,2,4,†
- 1Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), University of Florence, Florence 50139, Italy.
- 2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
- 3Nephrology, Dialysis and Transplantation Unit, Careggi University Hospital, Florence 50139, Italy.
- 4Nephrology and Dialysis Unit, Meyer Children’s University Hospital, Florence 50139, Italy.
- 5Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence 50139, Italy.
- 6Department of Urology, Careggi Hospital, University of Florence, Florence 50139, Italy.
- 7Department of Urology, Spedali Civili Hospital, University of Brescia, Brescia 25123, Italy.
- 8Department of Urology, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin 10043, Italy.
- 9Department of Urology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy.
- 10Department of Urology, University of Padua, Padua 35122, Italy.
- 11Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
- 12Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus 8200, Denmark.
- 13Unit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S., Scientific Institute of Pavia, Pavia 28100, Italy.
- 14Arkana Laboratories, Little Rock, AR 72211, USA.
- 15Division of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der LMU München, Munich 80336, Germany.
- 16Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence 50139, Italy.
- ↵†Corresponding author. Email: paola.romagnani{at}unifi.it
↵* Retired from the Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
See allHide authors and affiliations
Science Translational Medicine 25 Mar 2020:
Vol. 12, Issue 536, eaaw6003
DOI: 10.1126/scitranslmed.aaw6003
Vol. 12, Issue 536, eaaw6003
DOI: 10.1126/scitranslmed.aaw6003
Anna Julie Peired
1Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), University of Florence, Florence 50139, Italy.
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Giulia Antonelli
1Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), University of Florence, Florence 50139, Italy.
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Maria Lucia Angelotti
1Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), University of Florence, Florence 50139, Italy.
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Marco Allinovi
1Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), University of Florence, Florence 50139, Italy.
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
3Nephrology, Dialysis and Transplantation Unit, Careggi University Hospital, Florence 50139, Italy.
Francesco Guzzi
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Alessandro Sisti
4Nephrology and Dialysis Unit, Meyer Children’s University Hospital, Florence 50139, Italy.
Roberto Semeraro
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Carolina Conte
1Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), University of Florence, Florence 50139, Italy.
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Benedetta Mazzinghi
4Nephrology and Dialysis Unit, Meyer Children’s University Hospital, Florence 50139, Italy.
Sara Nardi
4Nephrology and Dialysis Unit, Meyer Children’s University Hospital, Florence 50139, Italy.
Maria Elena Melica
1Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), University of Florence, Florence 50139, Italy.
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Letizia De Chiara
4Nephrology and Dialysis Unit, Meyer Children’s University Hospital, Florence 50139, Italy.
Elena Lazzeri
1Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), University of Florence, Florence 50139, Italy.
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Laura Lasagni
1Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), University of Florence, Florence 50139, Italy.
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Tiziano Lottini
5Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence 50139, Italy.
Samuela Landini
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Sabrina Giglio
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Andrea Mari
6Department of Urology, Careggi Hospital, University of Florence, Florence 50139, Italy.
Fabrizio Di Maida
6Department of Urology, Careggi Hospital, University of Florence, Florence 50139, Italy.
Alessandro Antonelli
7Department of Urology, Spedali Civili Hospital, University of Brescia, Brescia 25123, Italy.
Francesco Porpiglia
8Department of Urology, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin 10043, Italy.
Riccardo Schiavina
9Department of Urology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy.
Vincenzo Ficarra
10Department of Urology, University of Padua, Padua 35122, Italy.
Davide Facchiano
6Department of Urology, Careggi Hospital, University of Florence, Florence 50139, Italy.
Mauro Gacci
6Department of Urology, Careggi Hospital, University of Florence, Florence 50139, Italy.
Sergio Serni
6Department of Urology, Careggi Hospital, University of Florence, Florence 50139, Italy.
Marco Carini
6Department of Urology, Careggi Hospital, University of Florence, Florence 50139, Italy.
George J. Netto
11Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Rosa Maria Roperto
4Nephrology and Dialysis Unit, Meyer Children’s University Hospital, Florence 50139, Italy.
Alberto Magi
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
Christian Fynbo Christiansen
12Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus 8200, Denmark.
Mario Rotondi
13Unit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S., Scientific Institute of Pavia, Pavia 28100, Italy.
Helen Liapis
14Arkana Laboratories, Little Rock, AR 72211, USA.
Hans-Joachim Anders
15Division of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der LMU München, Munich 80336, Germany.
Andrea Minervini
6Department of Urology, Careggi Hospital, University of Florence, Florence 50139, Italy.
Maria Rosaria Raspollini
16Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence 50139, Italy.
Paola Romagnani
1Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), University of Florence, Florence 50139, Italy.
2Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.
4Nephrology and Dialysis Unit, Meyer Children’s University Hospital, Florence 50139, Italy.
