Research ArticleCancer

Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells

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Science Translational Medicine  25 Mar 2020:
Vol. 12, Issue 536, eaaw6003
DOI: 10.1126/scitranslmed.aaw6003

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Kidneys’ immortal wounds

Tissue injury and repair can contribute to subsequent development of cancer, especially in the setting of chronic damage and repeated cycles of tissue repair. It appears that acute injury may have a similar effect, at least in the kidney. Peired et al. first analyzed data from multiple independent cohorts of human patients and demonstrated a correlation between acute kidney injury and subsequent development of papillary renal cancer and recurrence of cancer in patients who had undergone surgery to remove their initial tumors. The authors then studied human renal progenitor cells and mouse models to determine the underlying mechanism for kidney injury–induced carcinogenesis.

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