An ocular glymphatic clearance system removes β-amyloid from the rodent eye

Xiaowei Wang; Nanhong Lou; Allison Eberhardt; Yujia Yang; Peter Kusk; Qiwu Xu; Benjamin Förstera; Sisi Peng; Meng Shi; Antonio Ladrón-de-Guevara; Christine Delle; Björn Sigurdsson; Anna L. R. Xavier; Ali Ertürk; Richard T. Libby; Lu Chen; Alexander S. Thrane; Maiken Nedergaard

doi:10.1126/scitranslmed.aaw3210

Research ArticleEYE PHYSIOLOGY

An ocular glymphatic clearance system removes β-amyloid from the rodent eye

View ORCID ProfileXiaowei Wang¹,²,
Nanhong Lou²,
Allison Eberhardt²,
View ORCID ProfileYujia Yang³,
Peter Kusk¹,
View ORCID ProfileQiwu Xu²,
View ORCID ProfileBenjamin Förstera⁴,⁵,
View ORCID ProfileSisi Peng²,
View ORCID ProfileMeng Shi³,
View ORCID ProfileAntonio Ladrón-de-Guevara²,
View ORCID ProfileChristine Delle¹,
View ORCID ProfileBjörn Sigurdsson¹,
View ORCID ProfileAnna L. R. Xavier¹,
Ali Ertürk⁴,⁵,
View ORCID ProfileRichard T. Libby⁶,
View ORCID ProfileLu Chen ³,*,
View ORCID ProfileAlexander S. Thrane ¹,⁷ and
View ORCID ProfileMaiken Nedergaard ¹,²,*

¹Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
²Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
³Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.
⁴Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.
⁵Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center München, 85764 Munich, Germany.
⁶Department of Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA.
⁷Department of Ophthalmology, Haukeland University Hospital, Jonas Lies Vei 65, 5021 Bergen, Norway.

↵*Corresponding author. Email: nedergaard{at}sund.ku.dk (M.N.); chenlu{at}berkeley.edu (L.C.)

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Science Translational Medicine 25 Mar 2020:
Vol. 12, Issue 536, eaaw3210
DOI: 10.1126/scitranslmed.aaw3210

Xiaowei Wang

1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.

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ORCID record for Xiaowei Wang

Nanhong Lou

2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.

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Allison Eberhardt

2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.

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Yujia Yang

3Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.

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ORCID record for Yujia Yang

Peter Kusk

1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

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Qiwu Xu

2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.

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Benjamin Förstera

4Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.

5Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center München, 85764 Munich, Germany.

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Sisi Peng

2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.

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Meng Shi

3Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.

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Antonio Ladrón-de-Guevara

2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.

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Christine Delle

1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

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Björn Sigurdsson

1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

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Anna L. R. Xavier

1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

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Ali Ertürk

4Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.

5Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center München, 85764 Munich, Germany.

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Richard T. Libby

6Department of Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA.

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Lu Chen

3Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.

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For correspondence: nedergaard@sund.ku.dk chenlu@berkeley.edu

Alexander S. Thrane

1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

7Department of Ophthalmology, Haukeland University Hospital, Jonas Lies Vei 65, 5021 Bergen, Norway.

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Maiken Nedergaard

1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.

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ORCID record for Maiken Nedergaard
For correspondence: nedergaard@sund.ku.dk chenlu@berkeley.edu

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An ocular glymphatic clearance system removes β-amyloid from the rodent eye

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