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Research ArticleEYE PHYSIOLOGY
An ocular glymphatic clearance system removes β-amyloid from the rodent eye
- View ORCID ProfileXiaowei Wang1,2,
- Nanhong Lou2,
- Allison Eberhardt2,
- View ORCID ProfileYujia Yang3,
- Peter Kusk1,
- View ORCID ProfileQiwu Xu2,
- View ORCID ProfileBenjamin Förstera4,5,
- View ORCID ProfileSisi Peng2,
- View ORCID ProfileMeng Shi3,
- View ORCID ProfileAntonio Ladrón-de-Guevara2,
- View ORCID ProfileChristine Delle1,
- View ORCID ProfileBjörn Sigurdsson1,
- View ORCID ProfileAnna L. R. Xavier1,
- Ali Ertürk4,5,
- View ORCID ProfileRichard T. Libby6,
- View ORCID ProfileLu Chen3,*,
- View ORCID ProfileAlexander S. Thrane1,7 and
- View ORCID ProfileMaiken Nedergaard1,2,*
- 1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
- 2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
- 3Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.
- 4Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.
- 5Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center München, 85764 Munich, Germany.
- 6Department of Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA.
- 7Department of Ophthalmology, Haukeland University Hospital, Jonas Lies Vei 65, 5021 Bergen, Norway.
- ↵*Corresponding author. Email: nedergaard{at}sund.ku.dk (M.N.); chenlu{at}berkeley.edu (L.C.)
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Science Translational Medicine 25 Mar 2020:
Vol. 12, Issue 536, eaaw3210
DOI: 10.1126/scitranslmed.aaw3210
Vol. 12, Issue 536, eaaw3210
DOI: 10.1126/scitranslmed.aaw3210
Xiaowei Wang
1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Nanhong Lou
2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Allison Eberhardt
2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Yujia Yang
3Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.
Peter Kusk
1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
Qiwu Xu
2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Benjamin Förstera
4Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.
5Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center München, 85764 Munich, Germany.
Sisi Peng
2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Meng Shi
3Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.
Antonio Ladrón-de-Guevara
2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
Christine Delle
1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
Björn Sigurdsson
1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
Anna L. R. Xavier
1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
Ali Ertürk
4Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.
5Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center München, 85764 Munich, Germany.
Richard T. Libby
6Department of Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Lu Chen
3Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.
Alexander S. Thrane
1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
7Department of Ophthalmology, Haukeland University Hospital, Jonas Lies Vei 65, 5021 Bergen, Norway.
Maiken Nedergaard
1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
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