Research ArticleEYE PHYSIOLOGY

An ocular glymphatic clearance system removes β-amyloid from the rodent eye

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Science Translational Medicine  25 Mar 2020:
Vol. 12, Issue 536, eaaw3210
DOI: 10.1126/scitranslmed.aaw3210

Article Information

vol. 12 no. 536

PubMed: 
Print ISSN: 
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History: 
  • Received for publication December 14, 2018
  • Resubmitted August 24, 2019
  • Accepted for publication December 30, 2019
  • .

Author Information

  1. Xiaowei Wang1,2,
  2. Nanhong Lou2,
  3. Allison Eberhardt2,
  4. Yujia Yang3,
  5. Peter Kusk1,
  6. Qiwu Xu2,
  7. Benjamin Förstera4,5,
  8. Sisi Peng2,
  9. Meng Shi3,
  10. Antonio Ladrón-de-Guevara2,
  11. Christine Delle1,
  12. Björn Sigurdsson1,
  13. Anna L. R. Xavier1,
  14. Ali Ertürk4,5,
  15. Richard T. Libby6,
  16. Lu Chen3,*,
  17. Alexander S. Thrane1,7 and
  18. Maiken Nedergaard1,2,*
  1. 1Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
  2. 2Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.
  3. 3Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.
  4. 4Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.
  5. 5Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center München, 85764 Munich, Germany.
  6. 6Department of Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA.
  7. 7Department of Ophthalmology, Haukeland University Hospital, Jonas Lies Vei 65, 5021 Bergen, Norway.
  1. *Corresponding author. Email: nedergaard{at}sund.ku.dk (M.N.); chenlu{at}berkeley.edu (L.C.)

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