Research ArticleEYE PHYSIOLOGY

An ocular glymphatic clearance system removes β-amyloid from the rodent eye

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Science Translational Medicine  25 Mar 2020:
Vol. 12, Issue 536, eaaw3210
DOI: 10.1126/scitranslmed.aaw3210

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An eye-opening look at the glymphatic system

Similar to the brain, they eye is a privileged organ and lacks the classic lymphatic vessels responsible for the circulation of fluids and removal of waste products from peripheral organs. A glymphatic system has been demonstrated to be responsible of drainage of molecules, including amyloid-β (Aβ), from the brain. Now, Wang et al. demonstrated the existence of a glymphatic system in the rodent eye responsible for the removal of ocular Aβ via the optic nerve. In addition, the authors demonstrated that this clearance pathway was impaired in rodent models of glaucoma, suggesting that the glymphatic system in the eye might contribute to the disease pathophysiology.

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