25 March 2020
Vol 12, Issue 536

About The Cover

Cover image expansion

ONLINE COVER Kidney Confetti. This image depicts a developing papillary renal carcinoma in the kidney of a Confetti mouse, in which individual tubular epithelial cells in the kidney are tagged with different fluorochromes. Collagen IV is labeled in cyan, and all other colors are nonspecific fluorochromes marking individual kidney cells. These fluorochromes allow tracking of kidney development and evolution of incipient tumors. Using these mouse models as well as multiple cohorts of human patients, Peired et al. demonstrated that acute kidney injury increases the risk of subsequent papillary renal cancer and identified an underlying mechanism. [CREDIT: PAOLA ROMAGNANI]