18 March 2020
Vol 12, Issue 535

About The Cover

Cover image expansion

ONLINE COVER When Cilia Skip a Beat. This image shows epithelial cell cilia, which are cellular protrusions that beat in a coordinated manner to move mucus along the airways. Liu et al. developed an imaging workflow using super-resolution microscopy to visualize and quantify protein expression in cilia of human nasal airway cells. The authors detected cellular structural defects, altered ciliary beating, and mislocalized proteins in cells from patients with primary ciliary dyskinesia. This approach could aid diagnosis of this inherited disease which is caused by a multitude of mutations that impair cilia function. [CREDIT: LIU ET AL./SCIENCE TRANSLATIONAL MEDICINE]