Contents
18 March 2020
Vol 12, Issue 535
Vol 12, Issue 535
Review
- Priorities for developing respiratory syncytial virus vaccines in different target populations
About 38 candidate vaccines and monoclonal antibodies are in clinical development for treating respiratory syncytial virus in different populations.
Research Resource
- A quantitative super-resolution imaging toolbox for diagnosis of motile ciliopathies
Quantitative super-resolution imaging improves the diagnosis of primary ciliary dyskinesia.
Research Articles
- Systemic AAV9.LAMP2B injection reverses metabolic and physiologic multiorgan dysfunction in a murine model of Danon disease
AAV9.LAMP2B corrects metabolic and physiologic manifestations of a murine model of Danon disease.
- A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection
A urinary assay enables the noninvasive diagnosis of kidney transplant rejection in concordance with biopsy histology reports.
- Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure
Synthetic heparan sulfate protects against drug-induced acute liver failure by inhibiting the proinflammatory activity of HMGB1/RAGE axis.
- Strong vaccine responses during chemotherapy are associated with prolonged cancer survival
A strong vaccine-induced T cell response during standard-of-care chemotherapy correlates with survival in patients with advanced cervical cancer.
Report
- Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4+ T cell recovery can harbor replication-competent HIV despite viral suppression
In virally suppressed HIV-infected individuals on antiretroviral drug therapy, platelets harboring HIV correlate with poor immunological recovery.
Editors' Choice
- Hope on the horizon for inherited blindness
In a clinical trial, gene therapy for X-linked retinitis pigmentosa improved vision.
- Boosting immune responses against early breast cancer
Pembrolizumab combined with neoadjuvant chemotherapy improves therapeutic responses in patients with early triple-negative breast cancer.
- Not “dust” any neural stimulator
An untethered, ultrasound-powered milliscale device can stimulate peripheral nerves in rats.
Erratum
About The Cover
ONLINE COVER When Cilia Skip a Beat. This image shows epithelial cell cilia, which are cellular protrusions that beat in a coordinated manner to move mucus along the airways. Liu et al. developed an imaging workflow using super-resolution microscopy to visualize and quantify protein expression in cilia of human nasal airway cells. The authors detected cellular structural defects, altered ciliary beating, and mislocalized proteins in cells from patients with primary ciliary dyskinesia. This approach could aid diagnosis of this inherited disease which is caused by a multitude of mutations that impair cilia function. [CREDIT: LIU ET AL./SCIENCE TRANSLATIONAL MEDICINE]
