Research ArticleAlzheimer’s Disease

Neurophysiological signatures in Alzheimer’s disease are distinctly associated with TAU, amyloid-β accumulation, and cognitive decline

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Science Translational Medicine  11 Mar 2020:
Vol. 12, Issue 534, eaaz4069
DOI: 10.1126/scitranslmed.aaz4069

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Oscillatory signatures

Patients with Alzheimer’s disease (AD) present encephalographic alterations involving multiple brain oscillation frequencies. Whether and how these abnormalities correlate with AD neuropathology and cognitive abilities remained to be investigated. Now, Ranashinghe et al. used magnetoencephalographic imaging (MEGI), positron emission tomography with amyloid-beta (Aβ) and TAU tracers, and cognitive evaluation to show the existence of specific MEGI signatures that correlated with neuropathological abnormalities. Alpha and delta regional brain oscillation differentially correlated with TAU, Ab, and cognitive dysfunctions. The results suggest that MEGI could help the identification of therapeutic approaches for modulating AD neuropathology.

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