Research ArticleBIOMATERIALS

An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats

See allHide authors and affiliations

Science Translational Medicine  11 Mar 2020:
Vol. 12, Issue 534, eaay6853
DOI: 10.1126/scitranslmed.aay6853

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Building bone with a helpful hydrogel

From a materials’ perspective, bone regeneration in craniofacial defects can be challenging, particularly considering the aqueous environment of the oral cavity. Hasani-Sadrabadi and colleagues developed an injectable alginate-based adhesive hydrogel that encapsulated aggregates of gingival mesenchymal stem cells and osteoconductive hydroxyapatite microparticles. In a rat model of peri-implantitis, the hydrogel promoted bone regeneration around dental implants. The hydrogel’s biodegradation and mechanical properties could be tuned, suggesting it could be a useful tool for tissue engineering.

View Full Text

Stay Connected to Science Translational Medicine