Research ArticleCancer

Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies

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Science Translational Medicine  11 Mar 2020:
Vol. 12, Issue 534, eaax1315
DOI: 10.1126/scitranslmed.aax1315

Article Information

vol. 12 no. 534

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 24, 2019
  • Resubmitted September 9, 2019
  • Accepted for publication January 30, 2020
  • .

Author Information

  1. Brian H. Santich1,2,
  2. Jeong A. Park2,
  3. Hoa Tran2,
  4. Hong-Fen Guo2,
  5. Morgan Huse3 and
  6. Nai-Kong V. Cheung2,*
  1. 1Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  2. 2Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  3. 3Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  1. *Corresponding author. Email: cheungn{at}mskcc.org

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