Research ArticleCancer

Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies

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Science Translational Medicine  11 Mar 2020:
Vol. 12, Issue 534, eaax1315
DOI: 10.1126/scitranslmed.aax1315

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The specifics of bispecifics

T cell–bispecific antibodies, which are designed to bring T cells together with tumor cells and thereby promote tumor killing, have been attracting increasing attention for a variety of tumor types. These bispecific antibodies come in a variety of shapes, sizes, and configurations, with different studies offering different suggestions as to factors that influence the antibodies’ effectiveness. Santich et al. undertook a systematic effort to assess the various parameters involved in the antitumor effectiveness of a particular bispecific antibody, examining factors such as valency and spatial configuration, which should help inform the development of future bispecific antibodies.

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