Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors

Johanna M. Schafer; Brian D. Lehmann; Paula I. Gonzalez-Ericsson; Clayton B. Marshall; J. Scott Beeler; Lindsay N. Redman; Hailing Jin; Violeta Sanchez; Matthew C. Stubbs; Peggy Scherle; Kimberly N. Johnson; Quanhu Sheng; Joseph T. Roland; Joshua A. Bauer; Yu Shyr; Bapsi Chakravarthy; Bret C. Mobley; Scott W. Hiebert; Justin M. Balko; Melinda E. Sanders; Phillip C. C. Liu; Jennifer A. Pietenpol

doi:10.1126/scitranslmed.aaw8275

Research ArticleCancer

Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors

View ORCID ProfileJohanna M. Schafer¹,
View ORCID ProfileBrian D. Lehmann ²,³,*,
View ORCID ProfilePaula I. Gonzalez-Ericsson³,*,
View ORCID ProfileClayton B. Marshall¹,³,*,
View ORCID ProfileJ. Scott Beeler¹,
View ORCID ProfileLindsay N. Redman¹,
View ORCID ProfileHailing Jin³,
View ORCID ProfileVioleta Sanchez³,
View ORCID ProfileMatthew C. Stubbs⁴,
View ORCID ProfilePeggy Scherle⁵,
Kimberly N. Johnson³,
View ORCID ProfileQuanhu Sheng⁶,
View ORCID ProfileJoseph T. Roland⁷,
View ORCID ProfileJoshua A. Bauer ¹,⁸,
View ORCID ProfileYu Shyr⁶,
View ORCID ProfileBapsi Chakravarthy³,⁹,
View ORCID ProfileBret C. Mobley¹⁰,
Scott W. Hiebert ¹,³,
View ORCID ProfileJustin M. Balko ²,³,
Melinda E. Sanders³,¹⁰,
Phillip C. C. Liu¹¹ and
View ORCID ProfileJennifer A. Pietenpol ¹,³,†

¹Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.
²Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
³Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
⁴Incyte Corporation, Wilmington, DE 19803, USA.
⁵Prelude Therapeutics, Wilmington, DE 19803, USA.
⁶Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
⁷Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
⁸Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA.
⁹Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
¹⁰Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
¹¹Kymera Therapeutics, Cambridge, MA 02139, USA.

↵†Corresponding author. Email: j.pietenpol{at}vumc.org

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Translational Medicine 11 Mar 2020:
Vol. 12, Issue 534, eaaw8275
DOI: 10.1126/scitranslmed.aaw8275

Johanna M. Schafer

1Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Johanna M. Schafer

Brian D. Lehmann

2Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Brian D. Lehmann

Paula I. Gonzalez-Ericsson

3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Paula I. Gonzalez-Ericsson

Clayton B. Marshall

1Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Clayton B. Marshall

J. Scott Beeler

1Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for J. Scott Beeler

Lindsay N. Redman

1Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Lindsay N. Redman

Hailing Jin

3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Hailing Jin

Violeta Sanchez

3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Violeta Sanchez

Matthew C. Stubbs

4Incyte Corporation, Wilmington, DE 19803, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Matthew C. Stubbs

Peggy Scherle

5Prelude Therapeutics, Wilmington, DE 19803, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Peggy Scherle

Kimberly N. Johnson

3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Quanhu Sheng

6Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Quanhu Sheng

Joseph T. Roland

7Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Joseph T. Roland

Joshua A. Bauer

1Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

8Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Joshua A. Bauer

Yu Shyr

6Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yu Shyr

Bapsi Chakravarthy

3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

9Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Bapsi Chakravarthy

Bret C. Mobley

10Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Bret C. Mobley

Scott W. Hiebert

1Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Justin M. Balko

2Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Justin M. Balko

Melinda E. Sanders

3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

10Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Phillip C. C. Liu

11Kymera Therapeutics, Cambridge, MA 02139, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jennifer A. Pietenpol

1Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jennifer A. Pietenpol
For correspondence: j.pietenpol@vumc.org

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools