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Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors

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Science Translational Medicine  11 Mar 2020:
Vol. 12, Issue 534, eaaw8275
DOI: 10.1126/scitranslmed.aaw8275

Article Information

vol. 12 no. 534

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 28, 2019
  • Resubmitted October 14, 2019
  • Accepted for publication January 28, 2020
  • .

Author Information

  1. Johanna M. Schafer1,
  2. Brian D. Lehmann2,3,*,
  3. Paula I. Gonzalez-Ericsson3,*,
  4. Clayton B. Marshall1,3,*,
  5. J. Scott Beeler1,
  6. Lindsay N. Redman1,
  7. Hailing Jin3,
  8. Violeta Sanchez3,
  9. Matthew C. Stubbs4,
  10. Peggy Scherle5,
  11. Kimberly N. Johnson3,
  12. Quanhu Sheng6,
  13. Joseph T. Roland7,
  14. Joshua A. Bauer1,8,
  15. Yu Shyr6,
  16. Bapsi Chakravarthy3,9,
  17. Bret C. Mobley10,
  18. Scott W. Hiebert1,3,
  19. Justin M. Balko2,3,
  20. Melinda E. Sanders3,10,
  21. Phillip C. C. Liu11 and
  22. Jennifer A. Pietenpol1,3,
  1. 1Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.
  2. 2Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  3. 3Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  4. 4Incyte Corporation, Wilmington, DE 19803, USA.
  5. 5Prelude Therapeutics, Wilmington, DE 19803, USA.
  6. 6Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  7. 7Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  8. 8Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA.
  9. 9Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  10. 10Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  11. 11Kymera Therapeutics, Cambridge, MA 02139, USA.
  1. Corresponding author. Email: j.pietenpol{at}vumc.org
  • * These authors contributed equally to this work.

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