Research ArticleCancer

Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy

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Science Translational Medicine  11 Mar 2020:
Vol. 12, Issue 534, eaav7431
DOI: 10.1126/scitranslmed.aav7431

Article Information

vol. 12 no. 534

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 16, 2018
  • Resubmitted July 18, 2019
  • Accepted for publication February 17, 2020
  • .

Author Information

  1. Maud Mayoux1,
  2. Andreas Roller2,
  3. Vesna Pulko1,
  4. Stefano Sammicheli1,
  5. Stanford Chen1,
  6. Eva Sum1,
  7. Christian Jost1,
  8. Marieke F. Fransen3,
  9. Regula B. Buser1,
  10. Marcin Kowanetz4,
  11. Karolin Rommel1,
  12. Ines Matos1,
  13. Sara Colombetti1,
  14. Anton Belousov5,
  15. Vaios Karanikas1,
  16. Ferry Ossendorp3,
  17. Priti S. Hegde4,
  18. Daniel S. Chen6,
  19. Pablo Umana1,
  20. Mario Perro1,
  21. Christian Klein1 and
  22. Wei Xu1,*,
  1. 1Cancer Immunotherapy Discovery, Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren 8952, Switzerland.
  2. 2Pharmaceutical Sciences, Biomarkers, Bioinformatics and Omics & Pathology, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel 4070, Switzerland.
  3. 3Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden 2333, Netherlands.
  4. 4Oncology Biomarker Development, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  5. 5Pharmaceutical Sciences, Biomarkers, Bioinformatics and Omics, Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Penzberg 82377, Germany.
  6. 6Product Development, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  1. Corresponding author. Email: xu.wei{at}innoventbio.com
  • * Present address: Innovent Biologics Inc., 168 Dongping Street, Suzhou Industrial Park, Suzhou, China.

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