Contents
11 March 2020
Vol 12, Issue 534
Vol 12, Issue 534
Editorial
- New coronavirus outbreak: Framing questions for pandemic prevention
We need to understand and quantify the dominant variables that govern the SARS–CoV-2 outbreak, rather than relying exclusively on confirmed cases and their geospatial spread.
Research Articles
- Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors
This study demonstrates the potential utility of BET and MEK inhibitors for advanced MYCN-expressing triple-negative breast cancer.
- Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy
Tissue-engineered therapies targeting the nucleus pulposus and annulus fibrosus prevent intervertebral disc degeneration after discectomy in sheep.
- Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy
DCs are critical cellular targets of PD-L1 blockade in cancer treatment.
- An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats
A photocrosslinkable, cell-laden, adhesive hydrogel with tunable mechanical, osteoconductive, and biodegradative properties promotes bone formation.
- Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies
T cell–bispecific antibody antitumor function is maximized through optimal interdomain spacing and dual cis-configurations.
- Neurophysiological signatures in Alzheimer’s disease are distinctly associated with TAU, amyloid-β accumulation, and cognitive decline
Alpha and delta-theta brain oscillation deficits depict diverse associations with amyloid and TAU accumulations and with cognitive decline in AD.
Editors' Choice
- Hematopoietic maladaptation facilitates septic screening
Single-cell RNA sequencing of peripheral blood cells from patients with bacterial infections reveals a monocyte subset that can distinguish those at risk of sepsis.
- Trimming the “fatty” intratumoral Tregs for cancer immunotherapy
Fatty acid receptor CD36 preferentially regulates intratumoral but not peripheral Tregs.
- “You are what you eat!”
Single-cell transcriptomic analysis reveals how caloric restriction prevents aging at the cellular level.
About The Cover
ONLINE COVER Staying Abreast of Oncogenic MYC. This artistic rendering depicts a tumor that expresses MYC (green) and MYCN (magenta) after treatment that decreases both oncoproteins. MYCN plays a major oncogenic role in neuroectodermal tumors. However, when Schafer et al. analyzed tissue specimens from hundreds of patients with triple-negative breast cancer, they discovered that MYC and MYCN were expressed in the nuclei within many of the tumors. Using a high-throughput screen, the authors identified drug candidates with synergistic effects against MYCN-expressing triple-negative breast cancer in multiple models in vitro and in vivo. [CREDIT: JARED SCHAFER]
