11 March 2020
Vol 12, Issue 534

About The Cover

Cover image expansion

ONLINE COVER Staying Abreast of Oncogenic MYC. This artistic rendering depicts a tumor that expresses MYC (green) and MYCN (magenta) after treatment that decreases both oncoproteins. MYCN plays a major oncogenic role in neuroectodermal tumors. However, when Schafer et al. analyzed tissue specimens from hundreds of patients with triple-negative breast cancer, they discovered that MYC and MYCN were expressed in the nuclei within many of the tumors. Using a high-throughput screen, the authors identified drug candidates with synergistic effects against MYCN-expressing triple-negative breast cancer in multiple models in vitro and in vivo. [CREDIT: JARED SCHAFER]