Research ArticleObesity

GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats

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Science Translational Medicine  04 Mar 2020:
Vol. 12, Issue 533, eaay8071
DOI: 10.1126/scitranslmed.aay8071

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The pulse of weight loss

Liraglutide is an approved medication that is prescribed in part for its ability to lower food intake and body weight. Liraglutide is a known glucagon-like peptide-1 receptor (GLP-1R) agonist; however, how the drug affects the central nervous system to promote satiety is not fully elucidated. Fortin et al. identified a subset of GABAergic neurons in the nucleus tractus solitarius (NTS) that expressed GLP-1Rs and helped mediate the anorectic and weight-reducing effects of liraglutide in male rats. Knockdown of NTS Glp1r in the rats abrogated the food intake– and body weight–reducing effects of both acutely and chronically administered liraglutide.

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