A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees

Philip P. Vu; Alex K. Vaskov; Zachary T. Irwin; Phillip T. Henning; Daniel R. Lueders; Ann T. Laidlaw; Alicia J. Davis; Chrono S. Nu; Deanna H. Gates; R. Brent Gillespie; Stephen W. P. Kemp; Theodore A. Kung; Cynthia A. Chestek; Paul S. Cederna

doi:10.1126/scitranslmed.aay2857

Research ArticleNEUROTECHNOLOGY

A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees

View ORCID ProfilePhilip P. Vu¹,
View ORCID ProfileAlex K. Vaskov²,
Zachary T. Irwin¹,
View ORCID ProfilePhillip T. Henning³,
Daniel R. Lueders³,
Ann T. Laidlaw³,
View ORCID ProfileAlicia J. Davis⁴,
Chrono S. Nu¹,
View ORCID ProfileDeanna H. Gates¹,²,⁵,
View ORCID ProfileR. Brent Gillespie²,⁶,
Stephen W. P. Kemp⁷,
Theodore A. Kung⁷,
View ORCID ProfileCynthia A. Chestek ¹,²,⁸,⁹,*,† and
View ORCID ProfilePaul S. Cederna¹,⁷,*,†

¹Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
²Robotics Institute, University of Michigan, Ann Arbor, MI 48109, USA.
³Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA.
⁴University of Michigan Hospital Orthotics and Prosthetics Center, Ann Arbor, MI 48109, USA.
⁵School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.
⁶Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
⁷Section of Plastic Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
⁸Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA.
⁹Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.

↵*Corresponding author. Email: cchestek{at}umich.edu (C.A.C.); cederna{at}med.umich.edu (P.S.C.)

↵† These authors contributed equally to this work.

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Science Translational Medicine 04 Mar 2020:
Vol. 12, Issue 533, eaay2857
DOI: 10.1126/scitranslmed.aay2857

Philip P. Vu

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

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Alex K. Vaskov

2Robotics Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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Zachary T. Irwin

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

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Phillip T. Henning

3Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA.

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Daniel R. Lueders

3Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA.

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Ann T. Laidlaw

3Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA.

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Alicia J. Davis

4University of Michigan Hospital Orthotics and Prosthetics Center, Ann Arbor, MI 48109, USA.

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Chrono S. Nu

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

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Deanna H. Gates

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

2Robotics Institute, University of Michigan, Ann Arbor, MI 48109, USA.

5School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.

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R. Brent Gillespie

2Robotics Institute, University of Michigan, Ann Arbor, MI 48109, USA.

6Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

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Stephen W. P. Kemp

7Section of Plastic Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

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Theodore A. Kung

7Section of Plastic Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

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Cynthia A. Chestek

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

2Robotics Institute, University of Michigan, Ann Arbor, MI 48109, USA.

8Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA.

9Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.

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For correspondence: cchestek@umich.edu cederna@med.umich.edu

Paul S. Cederna

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

7Section of Plastic Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

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For correspondence: cchestek@umich.edu cederna@med.umich.edu

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