A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees

Philip P. Vu; Alex K. Vaskov; Zachary T. Irwin; Phillip T. Henning; Daniel R. Lueders; Ann T. Laidlaw; Alicia J. Davis; Chrono S. Nu; Deanna H. Gates; R. Brent Gillespie; Stephen W. P. Kemp; Theodore A. Kung; Cynthia A. Chestek; Paul S. Cederna

doi:10.1126/scitranslmed.aay2857

Research ArticleNEUROTECHNOLOGY

A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees

View ORCID ProfilePhilip P. Vu¹,
View ORCID ProfileAlex K. Vaskov²,
Zachary T. Irwin¹,
View ORCID ProfilePhillip T. Henning³,
Daniel R. Lueders³,
Ann T. Laidlaw³,
View ORCID ProfileAlicia J. Davis⁴,
Chrono S. Nu¹,
View ORCID ProfileDeanna H. Gates¹,²,⁵,
View ORCID ProfileR. Brent Gillespie²,⁶,
Stephen W. P. Kemp⁷,
Theodore A. Kung⁷,
View ORCID ProfileCynthia A. Chestek ¹,²,⁸,⁹,*,† and
View ORCID ProfilePaul S. Cederna¹,⁷,*,†

¹Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
²Robotics Institute, University of Michigan, Ann Arbor, MI 48109, USA.
³Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA.
⁴University of Michigan Hospital Orthotics and Prosthetics Center, Ann Arbor, MI 48109, USA.
⁵School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.
⁶Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
⁷Section of Plastic Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
⁸Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA.
⁹Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.

↵*Corresponding author. Email: cchestek{at}umich.edu (C.A.C.); cederna{at}med.umich.edu (P.S.C.)

↵† These authors contributed equally to this work.

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Science Translational Medicine 04 Mar 2020:
Vol. 12, Issue 533, eaay2857
DOI: 10.1126/scitranslmed.aay2857

Philip P. Vu

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

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Alex K. Vaskov

2Robotics Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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Zachary T. Irwin

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

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Phillip T. Henning

3Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA.

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Daniel R. Lueders

3Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA.

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Ann T. Laidlaw

3Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA.

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Alicia J. Davis

4University of Michigan Hospital Orthotics and Prosthetics Center, Ann Arbor, MI 48109, USA.

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Chrono S. Nu

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

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Deanna H. Gates

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

2Robotics Institute, University of Michigan, Ann Arbor, MI 48109, USA.

5School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.

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R. Brent Gillespie

2Robotics Institute, University of Michigan, Ann Arbor, MI 48109, USA.

6Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

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Stephen W. P. Kemp

7Section of Plastic Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

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Theodore A. Kung

7Section of Plastic Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

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Cynthia A. Chestek

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

2Robotics Institute, University of Michigan, Ann Arbor, MI 48109, USA.

8Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA.

9Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.

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For correspondence: cchestek@umich.edu cederna@med.umich.edu

Paul S. Cederna

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

7Section of Plastic Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

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For correspondence: cchestek@umich.edu cederna@med.umich.edu

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Hand(some) prosthetic technology

Neuroprosthetic devices providing tactile feedback sensation have been recently developed. Electrodes stimulating peripheral nerves have been shown to provide patients with the sense of touch and pressure when using upper limb prosthesis. Moreover, targeted muscle innervation can provide prosthesis control. However, the number of independent movements is still limited. Now, Vu et al. showed that regenerative peripheral nerve interfaces (RPNIs) implanted in upper limb amputees allowed the control of finger movements using hand prosthesis for almost a year without the need for adjustments. The results suggest that RNPIs could provide a stable and improved upper limb prosthesis control.

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A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees

Hand(some) prosthetic technology

Science Translational Medicine

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