Research ArticleCancer
High-dose vitamin C enhances cancer immunotherapy
- View ORCID ProfileAlessandro Magrì1,2,*,
- View ORCID ProfileGiovanni Germano1,2,*,
- View ORCID ProfileAnnalisa Lorenzato1,2,
- View ORCID ProfileSimona Lamba2,
- Rosaria Chilà1,3,
- View ORCID ProfileMonica Montone2,
- View ORCID ProfileVito Amodio1,2,
- Tommaso Ceruti4,
- Francesco Sassi2,
- View ORCID ProfileSabrina Arena1,2,
- View ORCID ProfileSergio Abrignani5,6,
- View ORCID ProfileMaurizio D’Incalci4,
- View ORCID ProfileMassimo Zucchetti4,
- View ORCID ProfileFederica Di Nicolantonio1,2,† and
- View ORCID ProfileAlberto Bardelli1,2,†
- 1Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.
- 2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.
- 3IFOM, The FIRC Institute of Molecular Oncology, 20139 Milan, Italy.
- 4Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
- 5Istituto Nazionale Genetica Molecolare INGM ‘Romeo ed Enrica Invernizzi’, 20122 Milan, Italy.
- 6Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
- ↵†Corresponding author. Email: alberto.bardelli{at}unito.it (A.B.); federica.dinicolantonio{at}unito.it (F.D.N.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 26 Feb 2020:
Vol. 12, Issue 532, eaay8707
DOI: 10.1126/scitranslmed.aay8707
Vol. 12, Issue 532, eaay8707
DOI: 10.1126/scitranslmed.aay8707
Alessandro Magrì
1Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.
2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.
Giovanni Germano
1Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.
2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.
Annalisa Lorenzato
1Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.
2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.
Simona Lamba
2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.
Rosaria Chilà
1Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.
3IFOM, The FIRC Institute of Molecular Oncology, 20139 Milan, Italy.
Monica Montone
2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.
Vito Amodio
1Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.
2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.
Tommaso Ceruti
4Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Francesco Sassi
2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.
Sabrina Arena
1Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.
2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.
Sergio Abrignani
5Istituto Nazionale Genetica Molecolare INGM ‘Romeo ed Enrica Invernizzi’, 20122 Milan, Italy.
6Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
Maurizio D’Incalci
4Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Massimo Zucchetti
4Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Federica Di Nicolantonio
1Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.
2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.
Alberto Bardelli
1Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.
2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy.
