Research ArticleCancer

High-dose vitamin C enhances cancer immunotherapy

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Science Translational Medicine  26 Feb 2020:
Vol. 12, Issue 532, eaay8707
DOI: 10.1126/scitranslmed.aay8707

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  • RE: High-does Vitamin C
    • Gerd Wasser, retired specialist for Internal Medicine, Prof. h.c. Henan University, First Peoples Hospital Zhenzhou, Henan Provinz, China

    Vitamin C acts under physiological dosages as an antioxidant and works in the soluble, aqueous phase. Oxidized Vit C will get regenerated by the fat soluble Vit E which in turn is transformed from the oxidized stage into the reduced one by the Glutathione oxidase/reductase.
    Thus, if one exceeds the regenerative capacity of the next compound (here Vit E) an overload of oxidized Vit C stays in action as a radical. Since tumours lack the antioxidative capacity needed to survive in a chronic low oxygen environment radiation and conventional chemotherapy work by inducing oxygen radicals.
    This might also be the effect if Vit E administered in lung tumours shortens the life expectancy.

    Competing Interests: None declared.

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