Contents
26 February 2020
Vol 12, Issue 532
Vol 12, Issue 532
Focus
- Natural killer cells get under your skin
Natural killer cells collaborate with type 2 immune cells to modulate atopic dermatitis pathogenesis (Mack et al., this issue).
Research Articles
- Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis
Patients with atopic dermatitis harbor deficiencies in subsets of NK cells that can be therapeutically reversed to improve disease in mice.
- Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with mucopolysaccharidosis type VII
In utero therapy with recombinant enzyme or hematopoietic stem cells in MPS7 mice induces tolerance to missing enzyme and corrects brain microglia.
- Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance
Liver macrophages exacerbate oxidative stress in obesity-induced hepatic steatosis by blocking the endogenous antioxidant response.
- Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces chemoresistance in glioblastoma
Glioblastoma-associated endothelial cells transform into mesenchymal stem cell–like cells via Wnt/β-catenin, inducing tumor resistance to chemotherapy.
- High-dose vitamin C enhances cancer immunotherapy
Vitamin C promotes anticancer adaptive immunity and enhances efficacy of immune checkpoint therapy.
Editors' Choice
- Echolocating electricity through the skull, in HD
Ultrasound can make high-resolution images of electrical fields across intact human skulls.
- Cell therapies can bring insult to injury
Some cell therapies increase the risk of thromboembolism in trauma patients due to high tissue factor expression.
- Boosting arginine metabolism to regress atherosclerosis?
The arginine metabolic pathway in macrophages is required to ensure continual efferocytosis and inflammation resolution.
About The Cover
ONLINE COVER Rebalancing Immunity. Here we see an illustration of the imbalanced immune response in the common inflammatory skin disease atopic dermatitis, with red type 2 immune cells weighing down the right scale. Mack et al. found that individuals with moderate to severe atopic dermatitis were deficient in subsets of natural killer (NK) cells, shown in blue on the left scale. Individuals who responded well to type 2-interrupting therapy experienced a restoration of their NK cell compartment. Moreover, an NK cell agonist reduced type 2 responses and relieved atopic dermatitis symptoms in a mouse model. These findings suggest that boosting NK cell function could rebalance immunity in atopic dermatitis. [CREDIT: MADISON MACK]
