26 February 2020
Vol 12, Issue 532

About The Cover

Cover image expansion

ONLINE COVER Rebalancing Immunity. Here we see an illustration of the imbalanced immune response in the common inflammatory skin disease atopic dermatitis, with red type 2 immune cells weighing down the right scale. Mack et al. found that individuals with moderate to severe atopic dermatitis were deficient in subsets of natural killer (NK) cells, shown in blue on the left scale. Individuals who responded well to type 2-interrupting therapy experienced a restoration of their NK cell compartment. Moreover, an NK cell agonist reduced type 2 responses and relieved atopic dermatitis symptoms in a mouse model. These findings suggest that boosting NK cell function could rebalance immunity in atopic dermatitis. [CREDIT: MADISON MACK]