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Research ArticleEpilepsy
Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations
- View ORCID ProfileLongbo Zhang1,2,
- Tianxiang Huang1,2,
- View ORCID ProfileShannon Teaw1,
- View ORCID ProfileLena H. Nguyen1,
- Lawrence S. Hsieh1,
- Xuan Gong1,2,
- View ORCID ProfileLindsay H. Burns3 and
- View ORCID ProfileAngélique Bordey1,*
- 1Departments of Neurosurgery and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520-8082, USA.
- 2Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Street, Changsha, Hunan 410008, China.
- 3Cassava Sciences Inc., Austin, TX 78731, USA.
- ↵*Corresponding author. Email: angelique.bordey{at}yale.edu
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Science Translational Medicine 19 Feb 2020:
Vol. 12, Issue 531, eaay0289
DOI: 10.1126/scitranslmed.aay0289
Vol. 12, Issue 531, eaay0289
DOI: 10.1126/scitranslmed.aay0289
Longbo Zhang
1Departments of Neurosurgery and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520-8082, USA.
2Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Street, Changsha, Hunan 410008, China.
Tianxiang Huang
1Departments of Neurosurgery and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520-8082, USA.
2Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Street, Changsha, Hunan 410008, China.
Shannon Teaw
1Departments of Neurosurgery and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520-8082, USA.
Lena H. Nguyen
1Departments of Neurosurgery and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520-8082, USA.
Lawrence S. Hsieh
1Departments of Neurosurgery and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520-8082, USA.
Xuan Gong
1Departments of Neurosurgery and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520-8082, USA.
2Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Street, Changsha, Hunan 410008, China.
Lindsay H. Burns
3Cassava Sciences Inc., Austin, TX 78731, USA.
Angélique Bordey
1Departments of Neurosurgery and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520-8082, USA.
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