Research ArticleAtherosclerosis

Long noncoding RNA SNHG12 integrates a DNA-PK–mediated DNA damage response and vascular senescence

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Science Translational Medicine  19 Feb 2020:
Vol. 12, Issue 531, eaaw1868
DOI: 10.1126/scitranslmed.aaw1868

Article Information

vol. 12 no. 531

PubMed: 
Print ISSN: 
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History: 
  • Received for publication November 30, 2018
  • Resubmitted August 27, 2019
  • Accepted for publication January 10, 2020
  • .

Author Information

  1. Stefan Haemmig1,*,
  2. Dafeng Yang1,2,*,
  3. Xinghui Sun1,
  4. Debapria Das1,
  5. Siavash Ghaffari3,
  6. Roberto Molinaro1,4,
  7. Lei Chen1,2,
  8. Yihuan Deng1,
  9. Dan Freeman1,
  10. Norman Moullan5,
  11. Yevgenia Tesmenitsky1,
  12. A.K.M. Khyrul Wara1,
  13. Viorel Simion1,
  14. Eugenia Shvartz1,
  15. James F. Lee6,
  16. Tianlun Yang2,
  17. Galina Sukova1,
  18. Jarrod A. Marto6,7,8,
  19. Peter H. Stone1,
  20. Warren L. Lee3,
  21. Johan Auwerx5,
  22. Peter Libby1 and
  23. Mark W. Feinberg1,
  1. 1Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Department of Cardiology, Xiangya Hospital, Central South University, 0731 Changsha, Hunan, China.
  3. 3Keenan Research Centre, St. Michael’s Hospital and Department of Biochemistry, University of Toronto, Toronto, ON M5B 1W8, Canada.
  4. 4School of Pharmacy, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.
  5. 5Laboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
  6. 6The Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  7. 7Departments of Cancer Biology and Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  8. 8Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  1. Corresponding author. Email: mfeinberg{at}bwh.harvard.edu
  • * These authors contributed equally to this work.

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