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Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

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Science Translational Medicine  12 Feb 2020:
Vol. 12, Issue 530, eaax6337
DOI: 10.1126/scitranslmed.aax6337

Article Information

vol. 12 no. 530

PubMed: 
Print ISSN: 
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History: 
  • Received for publication April 9, 2019
  • Accepted for publication October 11, 2019
  • .

Author Information

  1. Jesse M. Jaynes1,2,*,
  2. Rushikesh Sable3,*,
  3. Michael Ronzetti4,*,
  4. Wendy Bautista5,*,
  5. Zachary Knotts3,
  6. Abisola Abisoye-Ogunniyan2,6,
  7. Dandan Li3,
  8. Raul Calvo4,
  9. Myagmarjav Dashnyam4,
  10. Anju Singh4,
  11. Theresa Guerin5,
  12. Jason White2,
  13. Sarangan Ravichandran7,
  14. Parimal Kumar8,
  15. Keyur Talsania9,
  16. Vicky Chen9,
  17. Anghesom Ghebremedhin2,
  18. Balasubramanyam Karanam2,
  19. Ahmad Bin Salam2,
  20. Ruksana Amin2,
  21. Taivan Odzorig3,
  22. Taylor Aiken6,10,
  23. Victoria Nguyen3,
  24. Yansong Bian3,
  25. Jelani C. Zarif11,12,
  26. Amber E. de Groot13,14,
  27. Monika Mehta8,
  28. Lixin Fan15,
  29. Xin Hu4,
  30. Anton Simeonov4,
  31. Nathan Pate5,
  32. Mones Abu-Asab16,
  33. Marc Ferrer4,
  34. Noel Southall4,
  35. Chan-Young Ock17,
  36. Yongmei Zhao9,
  37. Henry Lopez18,
  38. Serguei Kozlov5,
  39. Natalia de Val19,20,
  40. Clayton C. Yates2,,
  41. Bolormaa Baljinnyam4,,
  42. Juan Marugan4, and
  43. Udo Rudloff3,
  1. 1College of Agriculture, Environment and Nutrition Sciences, Integrative Biosciences Program, Tuskegee University, Tuskegee, AL 36088, USA.
  2. 2Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.
  3. 3Rare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  4. 4National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  5. 5Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.
  6. 6Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  7. 7Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA.
  8. 8Sequencing Facility and Single Cell Analysis Facility, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA.
  9. 9CCR-SF Bioinformatics Group, Advanced Biomedical and Computational Sciences, Biomedical Informatics and Data Science, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA.
  10. 10Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
  11. 11Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  12. 12Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  13. 13James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
  14. 14Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
  15. 15Basic Science Program, Frederick National Laboratory for Cancer Research, SAXS Core Facility, Center for Cancer Research of the National Cancer Institute, Frederick, MD 21701, USA.
  16. 16Section of Histopathology, National Eye Institute, Bethesda, MD 20892, USA.
  17. 17Department of Hemato Oncology, Seoul National University Hospital, Seoul 03080, Korea.
  18. 18MuriGenics Inc., Vallejo, CA 94592, USA.
  19. 19Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA.
  20. 20Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 21701, USA.
  1. Corresponding author. Email: cyates{at}tuskegee.edu (C.C.Y.); baljinnb{at}mail.nih.gov (B.B.); maruganj{at}mail.nih.gov (J.M.); rudloffu{at}mail.nih.gov (U.R.)
  • * These authors contributed equally to this work.

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